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Descriptor English: Polypyrimidine Tract-Binding Protein
Descriptor Spanish: Proteína de Unión al Tracto de Polipirimidina
Descriptor proteína de unión al tracto de polipirimidina
Scope note: Proteína de unión al ARN que se une a regiones ricas en polipirimidina en los INTRONES de los ARN mensajeros. La proteína de unión al tracto de polipirimidina puede estar implicada en la regulación del AYUSTE ALTERNATIVO de los ARNm, ya que su presencia en una región intrónica de ARN, secuencia arriba de un EXÓN, inhibe el ayuste del exón en el producto ARNm final.
Descriptor Portuguese: Proteína de Ligação a Regiões Ricas em Polipirimidinas
Descriptor French: Protéine PTB
Entry term(s): PTB Protein
PTB Splicing Factor
Polypyrimidine Tract Binding Protein
Splicing Factor, PTB
Tract-Binding Protein, Polypyrimidine
p57 Cytoplasmic RNA Binding Protein
p57 Cytoplasmic RNA-Binding Protein
pPTB
Tree number(s): D12.776.157.725.829.250
D12.776.664.962.829.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D038941
Scope note: A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 139076-35-0
Previous Indexing: RNA-Binding Proteins (1991-2002)
Ribonucleoproteins (1991-2002)
Public MeSH Note: 2003; POLYPYRIMIDINE TRACT-BINDING PROTEIN was indexed under RIBONUCLEOPROTEINS & RNA-BINDING PROTEINS 1991-2002
History Note: 2003; use POLYPYRIMIDINE TRACT-BINDING PROTEIN (NM) 1991-2002
DeCS ID: 37409
Unique ID: D038941
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/07/05
Polypyrimidine Tract-Binding Protein - Preferred
Concept UI M0190270
Scope note A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Preferred term Polypyrimidine Tract-Binding Protein
Entry term(s) PTB Protein
PTB Splicing Factor
Polypyrimidine Tract Binding Protein
Splicing Factor, PTB
Tract-Binding Protein, Polypyrimidine
p57 Cytoplasmic RNA Binding Protein
p57 Cytoplasmic RNA-Binding Protein
pPTB



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