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Descriptor English: PTB-Associated Splicing Factor
Descriptor Spanish: Factor de Empalme Asociado a PTB
Descriptor Portuguese: Fator de Processamento Associado a PTB
Descriptor French: Facteur d'épissage associé à PTB
Entry term(s): PSF Splicing Factor
PTB Associated Splicing Factor
Polypyrimidine Tract Binding Protein Associated Splicing Factor
Polypyrimidine Tract-Binding Protein-Associated Splicing Factor
SFPQ Protein
Splicing Factor Proline Glutamine Rich Protein
Splicing Factor Proline-Glutamine Rich Protein
Splicing Factor, PSF
Splicing Factor, PTB-Associated
Tree number(s): D12.776.157.725.829.282
D12.776.260.693
D12.776.664.962.829.282
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072670
Scope note: An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; PTB-ASSOCIATED SPLICING FACTOR was indexed under RNA-BINDING PROTEINS 1993-2016
History Note: 2017 (1993)
Related: Polypyrimidine Tract-Binding Protein MeSH
DeCS ID: 56592
Unique ID: D000072670
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01
PTB-Associated Splicing Factor - Preferred
Concept UI M0214402
Scope note An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.
Preferred term PTB-Associated Splicing Factor
Entry term(s) PSF Splicing Factor
PTB Associated Splicing Factor
Polypyrimidine Tract Binding Protein Associated Splicing Factor
Polypyrimidine Tract-Binding Protein-Associated Splicing Factor
SFPQ Protein
Splicing Factor Proline Glutamine Rich Protein
Splicing Factor Proline-Glutamine Rich Protein
Splicing Factor, PSF
Splicing Factor, PTB-Associated



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