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Descriptor English: Integrin alphaVbeta3
Descriptor Spanish: Integrina alfaVbeta3
Descriptor integrina alfaVbeta3
Scope note: Integrina que se une a diversas proteínas plasmáticas y de la matriz extracelular que contienen la secuencia de aminoácidos RGD conservada y modula la adhesión celular. La integrina alfavbeta3 se expresa en grandes cantidades en los OSTEOCLASTOS, donde puede jugar un papel importante en la REABSORCIÓN ÓSEA. Asimismo, abunda en la musculatura lisa de los vasos, en las células endoteliales y en algunas células tumorales, donde está involucrada en la angiogénesis y en la migración celular. Aunque a menudo recibe la denominación de receptor de vitronectina, hay más de un receptor de vitronectina (RECEPTORES DE VITRONECTINA).
Descriptor Portuguese: Integrina alfaVbeta3
Descriptor French: Intégrine alphaVbêta3
Entry term(s): Integrin alpha v beta 3
Integrin alpha-v beta-3
Receptor, Vitronectin
Receptors, alpha v beta 3 Integrin
Receptors, alpha-v beta-3 Integrin
Vitronectin Receptor
alpha v beta 3 Integrin Receptors
alpha-v beta-3 Integrin Receptors
alpha-v beta-3, Integrin
alphaVbeta3, Integrin
beta-3, Integrin alpha-v
Tree number(s): D09.400.430.890.625.439
D12.776.395.550.625.439
D12.776.543.550.625.439
D12.776.543.750.705.408.460.870.500
D12.776.543.750.705.675.541
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039302
Scope note: An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Annotation: do not confuse entry term VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2003; see RECEPTORS, VITRONECTIN 1996-2002
History Note: 2003; use RECEPTORS, VITRONECTIN 1996-2002
DeCS ID: 37452
Unique ID: D039302
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/09
Integrin alphaVbeta3 - Preferred
Concept UI M0418730
Scope note An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Preferred term Integrin alphaVbeta3
Entry term(s) Integrin alpha v beta 3
Integrin alpha-v beta-3
Receptor, Vitronectin
Receptors, alpha v beta 3 Integrin
Receptors, alpha-v beta-3 Integrin
Vitronectin Receptor
alpha v beta 3 Integrin Receptors
alpha-v beta-3 Integrin Receptors
alpha-v beta-3, Integrin
alphaVbeta3, Integrin
beta-3, Integrin alpha-v



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