| Descriptor English: | Integrin alpha2beta1 | ||||
| Descriptor Spanish: |
Integrina alfa2beta1
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| Descriptor Portuguese: | Integrina alfa2beta1 | ||||
| Descriptor French: | Intégrine alpha2bêta1 | ||||
| Entry term(s): |
CD49b CD29 CD49b-CD29 Glycoprotein Ia IIa Glycoprotein Ia-IIa Late Antigen-2, Very Platelet Membrane Glycoprotein Heterodimer Ia IIa Platelet Membrane Glycoprotein Heterodimer Ia-IIa VLA 2 VLA-2 Very Late Antigen 2 Very Late Antigen-2 alpha2beta1, Integrin alpha2beta1Integrin |
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| Tree number(s): |
D12.776.395.550.625.298 D12.776.543.550.625.298 D12.776.543.750.685.200 D12.776.543.750.705.408.530.249 D12.776.543.750.705.408.850.199 D12.776.543.750.705.675.352 D12.776.543.750.705.876.280 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D038982 | ||||
| Scope note: | An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase. |
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| Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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| Previous Indexing: |
Collagen Receptors (1991-2002) Integrins (1994-2002) |
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| Public MeSH Note: | 2003; INTEGRIN ALPHA2BETA1 was indexed under INTEGRINS 1994-2002 |
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| History Note: | 2003; for VLA-2 use COLLAGEN RECEPTORS (NM) 1991-2002; for PLATELET MEMBRANE GLYCOPROTEIN HETERODIMER IA-IIA use COLLAGEN RECEPTORS (NM) 1992-2000; for INTEGRIN ALPHA2BETA1 & CD49B-CD29 use COLLAGEN RECEPTORS (NM) 1994-2002; for ALPHA2BETA1INTEGRIN use COLLAGEN RECEPTORS (NM) 2001-2002 |
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| DeCS ID: | 37449 | ||||
| Unique ID: | D038982 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2003/01/01 | ||||
| Date of Entry: | 2002/07/02 | ||||
| Revision Date: | 2016/06/17 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Integrin alpha2beta1
- Preferred
| Concept UI |
M0417889 |
| Scope note | An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase. |
| Preferred term | Integrin alpha2beta1 |
| Entry term(s) |
CD49b CD29 CD49b-CD29 Glycoprotein Ia IIa Glycoprotein Ia-IIa Late Antigen-2, Very Platelet Membrane Glycoprotein Heterodimer Ia IIa Platelet Membrane Glycoprotein Heterodimer Ia-IIa VLA 2 VLA-2 Very Late Antigen 2 Very Late Antigen-2 alpha2beta1, Integrin alpha2beta1Integrin |
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