Descriptor English: | Integrin alpha6beta1 | ||||
Descriptor Spanish: |
Integrina alfa6beta1
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Descriptor Portuguese: | Integrina alfa6beta1 | ||||
Descriptor French: | Intégrine alpha6bêta1 | ||||
Entry term(s): |
CD49f CD29 CD49f-CD29 Glycoprotein I'c-IIa, Platelet I'c-IIa, Platelet Glycoprotein Integrin alpha(6)beta(1) Integrin alpha6Abeta1 Integrin alpha6Bbeta1 Integrin, alpha6beta1 Platelet Glycoprotein I'c IIa Platelet Glycoprotein I'c-IIa VLA 6 VLA-6 alpha 6 beta 1 Integrin alpha6Abeta1, Integrin alpha6Bbeta1, Integrin alpha6beta1 Integrin alpha6beta1, Integrin |
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Tree number(s): |
D09.400.430.890.625.419 D12.776.395.550.625.419 D12.776.543.550.625.419 D12.776.543.750.705.408.850.674 D12.776.543.750.705.675.514 D12.776.543.750.705.876.500 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D039121 | ||||
Scope note: | A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner. |
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Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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Previous Indexing: |
Integrins (1992-2002) |
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Public MeSH Note: | 2003; INTEGRIN ALPHA5BETA1 was indexed under INTEGRINS 1992-2002 |
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History Note: | 2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002 |
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DeCS ID: | 37451 | ||||
Unique ID: | D039121 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 2003/01/01 | ||||
Date of Entry: | 2002/07/02 | ||||
Revision Date: | 2013/07/09 |
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CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Integrin alpha6beta1
- Preferred
Integrin alpha6Bbeta1
- Narrower
Integrin alpha6Abeta1
- Narrower
Concept UI |
M0208151 |
Scope note | A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner. |
Preferred term | Integrin alpha6beta1 |
Entry term(s) |
CD49f CD29 CD49f-CD29 Glycoprotein I'c-IIa, Platelet I'c-IIa, Platelet Glycoprotein Integrin alpha(6)beta(1) Integrin, alpha6beta1 Platelet Glycoprotein I'c IIa Platelet Glycoprotein I'c-IIa VLA 6 VLA-6 alpha 6 beta 1 Integrin alpha6beta1 Integrin alpha6beta1, Integrin |
Concept UI |
M0208150 |
Preferred term | Integrin alpha6Bbeta1 |
Entry term(s) |
alpha6Bbeta1, Integrin |
Concept UI |
M0208149 |
Preferred term | Integrin alpha6Abeta1 |
Entry term(s) |
alpha6Abeta1, Integrin |
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