DeCS

Descriptor English:

Integrin alpha6beta1

Descriptor Spanish:

Integrina alfa6beta1

Spanish from Spain

Descriptor

integrina alfa6beta1

Scope note:

Receptor de la superficie celular que media en la adhesión celular a la MATRIZ EXTRACELULAR y a otras células mediante la unión con la LAMININA. Está implicado en la migración celular, desarrollo embrionario, activación leucocitaria e invasividad de las células tumorales. La integrina alfa6beta1 es el principal receptor de laminina en las PLAQUETAS, LEUCOCITOS y muchas CÉLULAS EPITELIALES y unión del ligando que puede activar determinadas vías de transducción de señales. El empalme alternativo del dominio citoplasmático de la subunidad alfa6 (INTEGRINA ALFA6) da lugar a la formación de las isoformas A y B del heterodímero, que se expresan de forma tisular específica.

Descriptor Portuguese:

Integrina alfa6beta1

Descriptor French:

Intégrine alpha6bêta1

Entry term(s):

CD49f CD29
CD49f-CD29
Glycoprotein I'c-IIa, Platelet
I'c-IIa, Platelet Glycoprotein
Integrin alpha(6)beta(1)
Integrin alpha6Abeta1
Integrin alpha6Bbeta1
Integrin, alpha6beta1
Platelet Glycoprotein I'c IIa
Platelet Glycoprotein I'c-IIa
VLA 6
VLA-6
alpha 6 beta 1 Integrin
alpha6Abeta1, Integrin
alpha6Bbeta1, Integrin
alpha6beta1 Integrin
alpha6beta1, Integrin

Tree number(s):

D12.776.395.550.625.419
D12.776.543.550.625.419
D12.776.543.750.705.408.850.674
D12.776.543.750.705.675.514
D12.776.543.750.705.876.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D039121

Scope note:

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

Allowable Qualifiers:

AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure

Concept UI	M0208151
Scope note	A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Preferred term	Integrin alpha6beta1
Entry term(s)	CD49f CD29 CD49f-CD29 Glycoprotein I'c-IIa, Platelet I'c-IIa, Platelet Glycoprotein Integrin alpha(6)beta(1) Integrin, alpha6beta1 Platelet Glycoprotein I'c IIa Platelet Glycoprotein I'c-IIa VLA 6 VLA-6 alpha 6 beta 1 Integrin alpha6beta1 Integrin alpha6beta1, Integrin

Concept UI	M0208150
Preferred term	Integrin alpha6Bbeta1
Entry term(s)	alpha6Bbeta1, Integrin

Concept UI	M0208149
Preferred term	Integrin alpha6Abeta1
Entry term(s)	alpha6Abeta1, Integrin

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