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Descriptor English: Integrin alpha4
Descriptor Spanish: Integrina alfa4
Descriptor integrina alfa4
Entry term(s) antígenos CD49d
Scope note: Unica subunidad de integrina alfa que no contiene un dominio I, y en la que su punto de escisión proteolítica está hacia el medio de la porción extracelular del polipéptido en lugar de localizarse en la proximidad de la membrana, tal como ocurre en el caso de otras subunidades de integrinas alfa.
Descriptor Portuguese: Integrina alfa4
Descriptor French: Intégrine alpha4
Entry term(s): Antigens, CD49d
CD49d Antigen
CD49d Antigens
Integrin, alpha4
alpha4 Integrin
Tree number(s): D12.776.543.750.705.408.100.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039441
Scope note: An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 143198-26-9
Previous Indexing: Antigens, CD (1994-2002)
Public MeSH Note: 2003; ALPHA4 INTEGRIN (now INTEGRIN ALPHA4) was indexed under ANTIGENS, CD 1994-2002
History Note: 2003 (1994)
Related: Natalizumab MeSH
DeCS ID: 37489
Unique ID: D039441
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2017/05/31
Integrin alpha4 - Preferred
Concept UI M0228076
Scope note An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
Preferred term Integrin alpha4
Entry term(s) Antigens, CD49d
CD49d Antigen
CD49d Antigens
Integrin, alpha4
alpha4 Integrin



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