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Descriptor English: Integrin alpha6beta4
Descriptor Spanish: Integrina alfa6beta4
Descriptor integrina alfa6beta4
Scope note: Esta integrina es un componente clave de los HEMIDESMOSOMAS y es necesaria para su formación y mantenimiento en las células epiteliales. La integrina alfa6beta4 también se encuentra en los timocitos, fibroblastos y células de Schwann, dónde funciona como receptor de laminina (RECEPTORES DE LAMININA) y está implicada en la cicatrización de heridas, la migración celular y la invasividad tumoral.
Descriptor Portuguese: Integrina alfa6beta4
Descriptor French: Intégrine alpha6 bêta4
Entry term(s): A9 Antigen
Antigen, A9
Integrin alpha(6),beta(4)
Integrin, alpha6 beta4
Laminin-5 Receptor (alpha6beta4 Integrin)
TSP-180
Tumor Specific Protein 180 Complex
Tumor Specific Protein-180 Complex
alpha(6)beta(4) Epithelial Integrin
alpha(6)beta(4) Integrin
alpha6 beta4 Integrin
alpha6beta4, Integrin
beta4 Integrin, alpha6
Tree number(s): D12.776.543.750.705.408.460.170
D12.776.543.750.705.876.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039161
Scope note: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Antigens, Surface (1988-2002)
Integrins (1988-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA6BETA4 was indexed under INTEGRINS; & ANTIGENS, SURFACE 1988-2002.
History Note: 2003; use INTEGRIN ALPHA6BETA4 (NM) 1988-2002
DeCS ID: 37497
Unique ID: D039161
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/09
Integrin alpha6beta4 - Preferred
Concept UI M0154541
Scope note This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Preferred term Integrin alpha6beta4
Entry term(s) A9 Antigen
Antigen, A9
Integrin alpha(6),beta(4)
Integrin, alpha6 beta4
Laminin-5 Receptor (alpha6beta4 Integrin)
TSP-180
Tumor Specific Protein 180 Complex
Tumor Specific Protein-180 Complex
alpha(6)beta(4) Epithelial Integrin
alpha(6)beta(4) Integrin
alpha6 beta4 Integrin
alpha6beta4, Integrin
beta4 Integrin, alpha6



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