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Descriptor English: Integrin alpha1beta1
Descriptor Spanish: Integrina alfa1beta1
Descriptor integrina alfa1beta1
Scope note: La integrina alfa1beta1 funciona como receptor para la LAMININA y el COLÁGENO. Se expresa ampliamente durante el desarrollo, pero en los adultos es el receptor predominante de laminina (RECEPTORES DE LAMININA) en las CÉLULAS MUSCULARES LISAS maduras, donde es importante para el mantenimiento del fenotipo diferenciado de tales células. La integrina alfa1beta1 se encuentra también en los LINFOCITOS y en las células endoteliales microvasculares, y desempeña un papel en la angiogénesis. En las CÉLULAS DE SCHWANN y en las células de la cresta neural está relacionada con la migración celular. La integrina alfa1beta1 es conocida también como VLA-1 y CD49a-CD29.
Descriptor Portuguese: Integrina alfa1beta1
Descriptor French: Intégrine alpha1 bêta1
Entry term(s): CD49a-CD29
Integrin alpha(1)beta(1)
Integrin, alpha1beta1
VLA-1
alpha1beta1 Integrin
alpha1beta1, Integrin
Tree number(s): D12.776.543.750.685.100
D12.776.543.750.705.408.850.099
D12.776.543.750.705.876.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039222
Scope note: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Integrins (1994-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA1BETA1 was indexed under INTEGRINS 1994-2002
History Note: 2003; use INTEGRIN ALPHA1BETA1 (NM) 1994-2002
DeCS ID: 37480
Unique ID: D039222
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2016/06/17
Integrin alpha1beta1 - Preferred
Concept UI M0230961
Scope note Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Preferred term Integrin alpha1beta1
Entry term(s) CD49a-CD29
Integrin alpha(1)beta(1)
Integrin, alpha1beta1
VLA-1
alpha1beta1 Integrin
alpha1beta1, Integrin



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