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Descriptor English: Flap Endonucleases
Descriptor Spanish: Endonucleasas de ADN Solapado
Descriptor endonucleasas de solapas del ADN
Entry term(s) FEN-1
endonucleasa de ADN solapado
endonucleasa flap 1
endonucleasas de ADN solapado
endonucleasas de cadena sobrepuesta del ADN
endonucleasas de secuencias solapadas
endonucleasas de solapas
endonucleasas flap
nucleasa RTH-1
nucleasa homóloga 1 de RAD2
proteína Fen1
Scope note: Endonucleasas que eliminan secuencias nucleotídicas del extremo 5' de una estructura de ADN llamada "DNA flap" (dominio de ADN tricatenario). Dicha estructura se da en los ADN bicatenarios que contienen una interrupción en una de las cadenas, de modo que la porción 5' de la cadena anterior a la interrupción es demasiado larga y se solapa con el extremo 3' de la cadena posterior a la interrupción. Las endonucleasas flap escinden la cadena anterior de la estructura que contiene el solapamiento justo después del primer nucléotido apareado y con ello crean una muesca sellable.
Descriptor Portuguese: Endonucleases Flap
Descriptor French: Flap endonucleases
Entry term(s): Endonuclease-1, Flap
Endonucleases, Flap
FEN-1
Fen1 Protein
Flap Endonuclease
Flap Endonuclease 1
Flap Endonuclease-1
Nuclease, RTH-1
RAD2 Homolog 1 Nuclease
RAD2 Homolog-1 Nuclease
RTH 1 Nuclease
RTH-1 Nuclease
Tree number(s): D08.811.277.352.355.325.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D045585
Scope note: Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.-
Previous Indexing: Endodeoxyribonucleases (1994-2003)
Public MeSH Note: 2004; FLAP ENDONUCLEASES was indexed under ENDODEOYRIBONUCLEASES 1994-2003; FEN1 PROTEIN was indexed under EXODEOXYRIBNUCLEASES 1997-2003; RTH-1 NUCLEASE was indexed under EXODEOXYRIBNUCLEASES 1996-2003
History Note: 2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003
DeCS ID: 38146
Unique ID: D045585
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2017/05/24
Flap Endonucleases - Preferred
Concept UI M0228928
Scope note Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Preferred term Flap Endonucleases
Entry term(s) Endonucleases, Flap
Flap Endonuclease
Flap Endonuclease-1 - Narrower
Concept UI M0448833
Preferred term Flap Endonuclease-1
Entry term(s) Endonuclease-1, Flap
FEN-1
Fen1 Protein
Flap Endonuclease 1
Nuclease, RTH-1
RAD2 Homolog 1 Nuclease
RAD2 Homolog-1 Nuclease
RTH 1 Nuclease
RTH-1 Nuclease



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