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Descriptor English: Zinc Finger Nucleases
Descriptor Spanish: Nucleasas con Dedos de Zinc
Descriptor nucleasas con dedos de zinc
Entry term(s) nucleasa de dedos de zinc
Scope note: Nucleasas creadas mediante ingeniería genética que escinden el ADN a una distancia definida de secuencias específicas que son reconocidas por los DOMINIOS DE UNIÓN A ADN DEDOS DE ZINC. Constan de un dominio de escisión del ADN, adaptado de endonucleasas de ADN, fusionado con un dominio tipo dedo de zinc de unión a ADN.
Descriptor Portuguese: Nucleases de Dedos de Zinco
Descriptor French: Nucléases à doigts de zinc
Entry term(s): Finger Nuclease, Zinc
Finger Nucleases, Zinc
Nuclease, Zinc Finger
Nuclease, Zinc-Finger
Nucleases, Zinc Finger
Nucleases, Zinc-Finger
Zinc Finger Nuclease
Zinc-Finger Nuclease
Zinc-Finger Nucleases
Tree number(s): D08.811.277.352.335.350.925
D08.811.277.352.355.325.850
D12.776.828.300.990
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075804
Scope note: Genetically engineered nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by ZINC FINGER DNA-BINDING DOMAINS. They are composed of a DNA cleaving domain adapted from DNA endonucleases fused to a zinc finger DNA-binding domain.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.-
Previous Indexing: Endonucleases (2005-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57005
Unique ID: D000075804
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2020/05/27
Zinc Finger Nucleases - Preferred
Concept UI M000631470
Scope note Genetically engineered nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by ZINC FINGER DNA-BINDING DOMAINS. They are composed of a DNA cleaving domain adapted from DNA endonucleases fused to a zinc finger DNA-binding domain.
Preferred term Zinc Finger Nucleases
Entry term(s) Finger Nuclease, Zinc
Finger Nucleases, Zinc
Nuclease, Zinc Finger
Nuclease, Zinc-Finger
Nucleases, Zinc Finger
Nucleases, Zinc-Finger
Zinc Finger Nuclease
Zinc-Finger Nuclease
Zinc-Finger Nucleases



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