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Descriptor English: MRE11 Homologue Protein
Descriptor Spanish: Proteína Homóloga de MRE11
Descriptor proteína homóloga de MRE11
Entry term(s) proteína 1 homóloga del gen de recombinación meiótica 11
proteína MRE11A
Scope note: Componente del complejo MRN junto a Rad50 y nibrina. Conjuntamente ejercen una función crítica en la reparación de ROTURAS DEL ADN DE DOBLE CADENA, REPARACIÓN DEL ADN POR RECOMBINACIÓN, el mantenimiento de la integridad del TELÓMERO y en la MEIOSIS. La proteína MRE11, que contiene un motivo de unión a poli(ADP)-ribosa y se asocia a PARP1, posee actividad de endonucleasa monocatenaria y actividad de exonucleasa 3'-5' específica de doble cadena. Las mutaciones del gen MRE11 se asocian al trastorno tipo 1 de ATAXIA-TELANGIECTASIA.
Descriptor Portuguese: Proteína Homóloga a MRE11
Descriptor French: Protéine homologue de MRE11
Entry term(s): Homologue Protein, MRE11
MRE11A Protein
Meiotic Recombination 11 Homolog 1 Protein
Tree number(s): D08.811.277.352.335.350.650
D08.811.277.352.335.375.813
D08.811.277.352.355.325.600
D08.811.277.352.365.290.250
D12.776.157.687.495
D12.776.260.539
D12.776.660.720.495
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076228
Scope note: A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.-
Previous Indexing: DNA-Binding Proteins (1999-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57004
Unique ID: D000076228
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
MRE11 Homologue Protein - Preferred
Concept UI M000632480
Scope note A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Preferred term MRE11 Homologue Protein
Entry term(s) Homologue Protein, MRE11
MRE11A Protein
Meiotic Recombination 11 Homolog 1 Protein



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