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Descriptor English: Cytochrome-B(5) Reductase
Descriptor Spanish: Citocromo-B(5) Reductasa
Descriptor citocromo-B(5) reductasa
Scope note: FLAVOPROTEÍNA-oxidorreductasa que se presenta como enzima soluble y como enzima unida a membranas debido al CORTE Y EMPALME ALTERNANTE de un único ARNm. La forma soluble se encuentra fundamentalmente en los ERITROCITOS e interviene en la reducción de la METAHEMOGLOBINA. La forma de la enzima unida a membranas se halla principalmente en el RETÍCULO ENDOPLASMÁTICO y en la membrana externa mitocondrial, donde participa en la insaturación de los ÁCIDOS GRASOS, la biosíntesis del COLESTEROL y el metabolismo de los fármacos. Una deficiencia de esta enzima puede producir METAHEMOGLOBINEMIA.
Descriptor Portuguese: Citocromo-B(5) Redutase
Descriptor French: Cytochrome-B(5) reductase
Entry term(s): B5 Reductase, NADH-Cytochrome
Methemoglobin Reductase
Methemoglobin Reductase, NADH
NADH Cytochrome B5 Reductase
NADH Ferrihemoglobin Reductase
NADH Methemoglobin Reductase
NADH-Cytochrome B5 Reductase
NADH-Ferrihemoglobin Reductase
Reductase, Methemoglobin
Reductase, NADH Methemoglobin
Reductase, NADH-Ferrihemoglobin
Tree number(s): D08.811.682.608.191.237
D12.776.331.186
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D042966
Scope note: A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Annotation: /defic: consider also METHEMOGLOBINEMIA
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.6.2.2
Previous Indexing: Cytochrome Reductases (1975-2003)
NADH, NADPH Oxidoreductases (1975-1990)
Oxidoreductases (1973-1974)
Public MeSH Note: 2004; CYTOCHROME B(5)REDUCTASE was indexed under CYTOCHROME REDUCTASES 1975-2003 & under OXIDOREDUCTASES 1973-1974; for METHEMOGLOBIN REDUCTASE see METHEMOGLOBIN REDUCTASE 1991-2003, see NADH, NADPH OXIDOREDUCTASES 1975-1990
History Note: 2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
DeCS ID: 38212
Unique ID: D042966
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Cytochrome-B(5) Reductase - Preferred
Concept UI M0073097
Scope note A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Preferred term Cytochrome-B(5) Reductase
Entry term(s) B5 Reductase, NADH-Cytochrome
NADH Cytochrome B5 Reductase
NADH-Cytochrome B5 Reductase
Methemoglobin Reductase - Narrower
Concept UI M0013564
Scope note The soluble, erythrocyte form of cytochrome-B(5) reductase. It catalyzes the reduction of methemoglobin (ferrihemoglobin) to hemoglobin (ferrohemoglobin).
Preferred term Methemoglobin Reductase
Entry term(s) Methemoglobin Reductase, NADH
NADH Ferrihemoglobin Reductase
NADH Methemoglobin Reductase
NADH-Ferrihemoglobin Reductase
Reductase, Methemoglobin
Reductase, NADH Methemoglobin
Reductase, NADH-Ferrihemoglobin



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