| Descriptor English: | NADPH Oxidases | ||||||
| Descriptor Spanish: |
NADPH Oxidasas
| ||||||
| Descriptor Portuguese: | NADPH Oxidases | ||||||
| Descriptor French: | NADPH oxidase | ||||||
| Entry term(s): |
NAD(P)H Oxidases NAD(P)H oxidase NADPH Oxidase Nox Proteins Oxidase, NADPH Oxidases, NADPH |
||||||
| Tree number(s): |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653 |
||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019255 | ||||||
| Scope note: | A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC. |
||||||
| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
||||||
| Registry Number: | EC 1.6.3.- | ||||||
| Previous Indexing: |
NADH, NADPH Oxidoreductases (1979-1996) NADP (1972-1980) Oxidoreductases (1972-1978) |
||||||
| Public MeSH Note: | 2018; see NADPH OXIDASE 1997-2017; NAD(P)H OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 2000-2005; NADPH OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 1979-1996, NADP 1972-1980 & OXIDOREDUCTASES 1972-1978 |
||||||
| History Note: | 2018 (1997) |
||||||
| Related: |
Granulomatous Disease, Chronic
MeSH | ||||||
| DeCS ID: | 33021 | ||||||
| Unique ID: | D019255 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/10 | ||||||
| Revision Date: | 2018/06/12 |
-
-
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
|
NADPH Oxidases
- Preferred
| Concept UI |
M0028676 |
| Scope note | A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC. |
| Preferred term | NADPH Oxidases |
| Entry term(s) |
NAD(P)H Oxidases NAD(P)H oxidase NADPH Oxidase Nox Proteins Oxidase, NADPH Oxidases, NADPH |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
