| Descriptor English: | Apoptosis Inducing Factor | ||||||
| Descriptor Spanish: |
Factor Inductor de la Apoptosis
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| Descriptor Portuguese: | Fator de Indução de Apoptose | ||||||
| Descriptor French: | Facteur inducteur d'apoptose | ||||||
| Entry term(s): |
AIF Apoptosis Regulatory Protein Apoptosis-Inducing Factor Apoptosis-Inducing Factor, Mitochondrial Mitochondrial Apoptosis Inducing Factor Mitochondrial Apoptosis-Inducing Factor |
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| Tree number(s): |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051033 | ||||||
| Scope note: | A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation. |
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| Annotation: | INHIBITOR OF APOPTOSIS PROTEINS is also available |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2006; APOPTOSIS INDUCING FACTOR was indexed under FLAVOPROTEINS & MEMBRANE PROTEINS 1999-2005 |
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| History Note: | 2006(1999) |
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| DeCS ID: | 50601 | ||||||
| Unique ID: | D051033 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Apoptosis Inducing Factor
- Preferred
| Concept UI |
M0301106 |
| Scope note | A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation. |
| Preferred term | Apoptosis Inducing Factor |
| Entry term(s) |
AIF Apoptosis Regulatory Protein Apoptosis-Inducing Factor Apoptosis-Inducing Factor, Mitochondrial Mitochondrial Apoptosis Inducing Factor Mitochondrial Apoptosis-Inducing Factor |
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