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Descriptor English: Protein Kinase C-alpha
Descriptor Spanish: Proteína Quinasa C-alfa
Descriptor proteína cinasa C-alfa
Entry term(s) PKC-alfa serina-treonina cinasa
PKC-alfa serina-treonina quinasa
proteincinasa C-alfa
proteinquinasa C-alfa
proteína quinasa C-alfa
Scope note: Serina treonina cinasa citoplásmica implicada en la regulación de la DIFERENCIACIÓN CELULAR y de la PROLIFERACIÓN CELULAR. Se ha demostrado que la sobreexpresión de esta enzima promueve la FOSFORILACIÓN DE LAS PROTEÍNAS PROTOONCOGÉNICAS BCL-2 y la quimiorresistencia en las células de la leucemia aguda humana.
Descriptor Portuguese: Proteína Quinase C-alfa
Descriptor French: Protein kinase C-alpha
Entry term(s): PKC alpha Serine Threonine Kinase
PKC-alpha Serine-Threonine Kinase
Protein Kinase C alpha
Protein Kinase C(alpha)
Serine-Threonine Kinase, PKC-alpha
Tree number(s): D08.811.913.696.620.682.700.725.100
D12.776.476.563.725.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051571
Scope note: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.13
Public MeSH Note: 2006; PROTEIN KINASE C ALPHA was indexed under PROTEIN KINASE C 2004-2006, & under ISOENZYMES 1999-2003
History Note: 2006(1999)
DeCS ID: 50721
Unique ID: D051571
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/06
Protein Kinase C-alpha - Preferred
Concept UI M0233036
Scope note A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
Preferred term Protein Kinase C-alpha
Entry term(s) PKC alpha Serine Threonine Kinase
PKC-alpha Serine-Threonine Kinase
Protein Kinase C alpha
Protein Kinase C(alpha)
Serine-Threonine Kinase, PKC-alpha



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