DeCS

Descriptor English:

Protein Kinase C

Descriptor Spanish:

Proteína Quinasa C

Spanish from Spain

Descriptor	proteína cinasa C
Entry term(s)	cinasa dependiente de fosfolípidos activada por el calcio proteína cinasa dependiente de calcio y fosfolípidos proteína quinasa C serintreonincinasa PKC
Scope note:	Proteína cinasa serina-treonina que requiere la presencia de concentraciones fisiológicas de CALCIO y FOSFOLÍPIDOS de membrana. La presencia adicional de DIACILGLICEROLES aumenta considerablemente su sensibilidad, tanto al calcio como a los fosfolípidos. La sensibilidad de la enzima también puede ser aumentada por ÉSTERES DE FORBOL y se considera que la cinasa C es la proteína receptora de los ésteres de forbol promotores de tumores.

Descriptor Portuguese:

Proteína Quinase C

Descriptor French:

Protéine kinase C

Entry term(s):

Calcium Activated Phospholipid Dependent Kinase
Calcium Phospholipid Dependent Protein Kinase
Calcium Phospholipid-Dependent Protein Kinase
Calcium-Activated Phospholipid-Dependent Kinase
PKC Serine Threonine Kinase
PKC Serine-Threonine Kinase
Phospholipid Sensitive Calcium Dependent Protein Kinase
Phospholipid-Dependent Kinase, Calcium-Activated
Phospholipid-Sensitive Calcium-Dependent Protein Kinase
Protein Kinase M
Serine-Threonine Kinase, PKC

Tree number(s):

D08.811.913.696.620.682.700.725
D12.776.476.563.725

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D011493

Scope note:

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0017861
Scope note	An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Preferred term	Protein Kinase C
Entry term(s)	Calcium Activated Phospholipid Dependent Kinase Calcium Phospholipid Dependent Protein Kinase Calcium Phospholipid-Dependent Protein Kinase Calcium-Activated Phospholipid-Dependent Kinase PKC Serine Threonine Kinase PKC Serine-Threonine Kinase Phospholipid Sensitive Calcium Dependent Protein Kinase Phospholipid-Dependent Kinase, Calcium-Activated Phospholipid-Sensitive Calcium-Dependent Protein Kinase Serine-Threonine Kinase, PKC

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