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Descriptor English: Protein Kinase C-theta
Descriptor Spanish: Proteína Quinasa C-theta
Descriptor proteína quinasa C-theta
Entry term(s) PKC-theta
PRKCQ
proteína cinasa C theta
Scope note: Subtipo de proteína cinasa C, dependiente de fosfolípido y diacilglicerol e independiente de calcio, que contiene un DOMINIO C2 N-terminal y dos DEDOS DE ZINC de unión a diacilglicerol. Se expresa principalmente en los LINFOCITOS T y se localiza en las SINAPSIS INMUNOLÓGICAS donde regula la señalización descendente de la activación, proliferación y supervivencia de los linfocitos T maduros. Tiene un papel crítico en las respuestas alérgicas, autoinmunitarias y aloinmunitarias de las CÉLULAS TH2 y las CÉLULAS TH17.
Descriptor Portuguese: Proteína Quinase C-theta
Descriptor French: Protein Kinase C-theta
Entry term(s): PKC theta
PKC-theta
PRKCQ
Protein Kinase C theta
Protein Kinase C, theta
Tree number(s): D08.811.913.696.620.682.700.725.075
D12.776.476.563.725.075
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074121
Scope note: A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.13
Previous Indexing: Isoenzymes (1992-2017)
Protein Kinase C (1992-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57032
Unique ID: D000074121
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
Protein Kinase C-theta - Preferred
Concept UI M000625701
Scope note A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
Preferred term Protein Kinase C-theta
Entry term(s) PKC theta
PKC-theta
PRKCQ
Protein Kinase C theta
Protein Kinase C, theta



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