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Descriptor English: Microphthalmia-Associated Transcription Factor
Descriptor Spanish: Factor de Transcripción Asociado a Microftalmía
Descriptor factor de transcripción asociado a la microftalmía
Entry term(s) factor de transcripción asociado a microftalmía
Scope note: Factor de transcripción con motivos hélice-bucle-hélice básicos y cremalleras de leucina que regulan la DIFERENCIACIÓN CELULAR y el desarrollo de diversos tipos celulares, como MELANOCITOS, OSTEOCLASTOS y EPITELIO PIGMENTADO DE LA RETINA. Las mutaciones de la proteína MITF se han asociado a OSTEOPETROSIS y SÍNDROME DE WAARDENBURG.
Descriptor Portuguese: Fator de Transcrição Associado à Microftalmia
Descriptor French: Facteur de transcription associé à la microphtalmie
Entry term(s): MITF Protein
MITF Transcription Factor
Microphthalmia Associated Transcription Factor
Microphthalmia, Transcription Factor
Transcription Factor Microphthalmia
Transcription Factor, Microphthalmia-Associated
Tree number(s): D12.776.260.103.500.500
D12.776.260.108.092.500
D12.776.930.125.500.500
D12.776.930.127.092.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051739
Scope note: A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1993-2005
History Note: 2006(1993)
DeCS ID: 50944
Unique ID: D051739
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2012/07/03
Microphthalmia-Associated Transcription Factor - Preferred
Concept UI M0219714
Scope note A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
Preferred term Microphthalmia-Associated Transcription Factor
Entry term(s) MITF Protein
MITF Transcription Factor
Microphthalmia Associated Transcription Factor
Microphthalmia, Transcription Factor
Transcription Factor Microphthalmia
Transcription Factor, Microphthalmia-Associated



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