| Descriptor English: | N-Myc Proto-Oncogene Protein | ||||||
| Descriptor Spanish: |
Proteína Proto-Oncogénica N-Myc
| ||||||
| Descriptor Portuguese: | Proteína Proto-Oncogênica N-Myc | ||||||
| Descriptor French: | Protéine du proto-oncogène N-Myc | ||||||
| Entry term(s): |
BHLHE37 Protein Class E Basic Helix Loop Helix Protein 37 Class E Basic Helix-Loop-Helix Protein 37 MYCN Protein N Myc Protein N Myc Proto Oncogene Protein N-Myc Protein NMYC Protein Proto-Oncogene Protein, N-Myc |
||||||
| Tree number(s): |
D12.776.260.103.500.625 D12.776.260.108.092.625 D12.776.624.664.700.158 D12.776.930.125.500.563 D12.776.930.127.092.625 |
||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071447 | ||||||
| Scope note: | A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer. |
||||||
| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
||||||
| Previous Indexing: |
Nuclear Proteins (2002-2016) Oncogene Proteins (2002-2016) Proto-Oncogene Proteins (2012-2016) |
||||||
| Public MeSH Note: | 2017 |
||||||
| History Note: | 2017 |
||||||
| DeCS ID: | 56596 | ||||||
| Unique ID: | D000071447 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/04/15 |
-
-
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
|
N-Myc Proto-Oncogene Protein
- Preferred
| Concept UI |
M000614703 |
| Scope note | A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer. |
| Preferred term | N-Myc Proto-Oncogene Protein |
| Entry term(s) |
BHLHE37 Protein Class E Basic Helix Loop Helix Protein 37 Class E Basic Helix-Loop-Helix Protein 37 MYCN Protein N Myc Protein N Myc Proto Oncogene Protein N-Myc Protein NMYC Protein Proto-Oncogene Protein, N-Myc |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
