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Descriptor English: Transcription Factor 4
Descriptor Spanish: Factor de Transcripción 4
Descriptor factor de transcripción 4
Entry term(s) factor de transcripción TCF-4
factor de transcripción TCF4
proteína TCF-4
Scope note: Factor de transcripción de estructura hélice-bucle-hélice básica (bHLH) en cremallera de leucina que actúa en la DIFERENCIACIÓN CELULAR neuronal. Dimeriza con otros factores de transcripción bHLH y activa la transcripción mediante unión a ELEMENTOS E-BOX que contienen secuencias 5'-ACANNTGT-3' o 5'-CCANNTGG-3'. Las mutaciones del gen TCF-4 se asocian al síndrome de Pitt-Hopkins, una grave alteración del desarrollo.
Descriptor Portuguese: Fator de Transcrição 4
Descriptor French: Facteur-4 de transcription
Entry term(s): TCF 4 Protein
TCF 4 Transcription Factor
TCF-4 Protein
TCF-4 Transcription Factor
TCF4 Transcription Factor
Transcription Factor, TCF-4
Transcription Factor, TCF4
Tree number(s): D12.776.260.108.092.937
D12.776.930.125.500.937
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073940
Scope note: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017)
Transcription Factors (2008-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57107
Unique ID: D000073940
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
Transcription Factor 4 - Preferred
Concept UI M000625038
Scope note A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Preferred term Transcription Factor 4
Entry term(s) TCF 4 Protein
TCF 4 Transcription Factor
TCF-4 Protein
TCF-4 Transcription Factor
TCF4 Transcription Factor
Transcription Factor, TCF-4
Transcription Factor, TCF4



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