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Descriptor English: TYK2 Kinase
Descriptor Spanish: TYK2 Quinasa
Descriptor TYK2 cinasa
Scope note: Subtipo de cinasa Janus implicada en la señalización de una amplia variedad de RECEPTORES DE CITOCINAS. Se considera que la TYK2 cinasa es el miembro fundador de la familia de cinasas Janus y fue descubierta inicialmente como socio señalizador del RECEPTOR DE INTERFERON ALFA-BETA. Desde entonces se ha demostrado que la cinasa señaliza a partir de varios RECEPTORES DE INTERLEUCINAS.
Descriptor Portuguese: TYK2 Quinase
Descriptor French: TYK2 Kinase
Entry term(s): Kinase, TYK2
Non Receptor Tyrosine Protein Kinase TYK2
Non-Receptor Tyrosine-Protein Kinase TYK2
Tyrosine Kinase 2
Tree number(s): D08.811.913.696.620.682.725.124.650
D12.776.476.568.124.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053634
Scope note: A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.10.2
Previous Indexing: Protein-Tyrosine Kinase (1991-2006)
Public MeSH Note: 2007
History Note: 2007
Related: src Homology Domains MeSH
DeCS ID: 52256
Unique ID: D053634
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/11/24
TYK2 Kinase - Preferred
Concept UI M0495106
Scope note A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
Preferred term TYK2 Kinase
Entry term(s) Kinase, TYK2
Non Receptor Tyrosine Protein Kinase TYK2
Non-Receptor Tyrosine-Protein Kinase TYK2
Tyrosine Kinase 2



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