| Descriptor English: | Janus Kinases | ||||||
| Descriptor Spanish: |
Quinasas Janus
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| Descriptor Portuguese: | Janus Quinases | ||||||
| Descriptor French: | Janus kinases | ||||||
| Entry term(s): |
JAK Kinases Janus Kinase Kinase, Janus Kinases, JAK Kinases, Janus |
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| Tree number(s): |
D08.811.913.696.620.682.725.124 D12.776.476.568.124 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D053612 | ||||||
| Scope note: | A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.2 | ||||||
| Public MeSH Note: | 2007 |
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| History Note: | 2007 |
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| Related: |
src Homology Domains
MeSH | ||||||
| DeCS ID: | 52252 | ||||||
| Unique ID: | D053612 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2007/01/01 | ||||||
| Date of Entry: | 2006/07/05 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Janus Kinases
- Preferred
| Concept UI |
M0495016 |
| Scope note | A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains. |
| Preferred term | Janus Kinases |
| Entry term(s) |
JAK Kinases Janus Kinase Kinase, Janus Kinases, JAK Kinases, Janus |
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