DeCS

Descriptor English:

src Homology Domains

Descriptor Spanish:

Dominios Homologos src

Spanish from Spain

Descriptor	dominios de homología src
Entry term(s)	dominio SH1 dominio SH2 dominio SH3 dominios SH dominios SH1 dominios SH2 dominios SH3
Scope note:	Dominios con SECUENCIAS DE AMINOÁCIDOS similares a la FAMILIA SRC DE TIROSINCINASAS, que se pliegan en estructuras terciarias funcionales especificas. El dominio SH1 es un dominio catalítico. Los dominios SH2 y SH3 son dominios de interacción proteínica. El dominio SH2 generalmente se une a proteínas que contienen FOSFOTIROSINA, mientras que el dominio SH3 interactúa con PROTEÍNAS CITOESQUELÉTICAS.

Descriptor Portuguese:

Domínios de Homologia de src

Descriptor French:

Domaine d'homologie SRC

Entry term(s):

Homology Domain, src
Homology Domains, src
SH Domain
SH Domains
SH1 Domain
SH1 Domains
SH2 Domain
SH2 Domains
SH3 Domain
SH3 Domains
src Homology Domain
src Homology Region 2 Domain

Tree number(s):

G02.111.570.820.709.275.750.500.750

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D018909

Scope note:

Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

Amino Acid Sequence (1989-1995)
Sequence Homology, Amino Acid (1993-1995)

Public MeSH Note:

History Note:

Entry Version:

SRC HOMOL DOMAINS

DeCS ID:

32604

Unique ID:

D018909

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1996/01/01

Date of Entry:

1995/01/06

Revision Date:

2016/05/31

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Protein Domains [G02.111.570.820.709.275.750]

Protein Domains

Protein Interaction Domains and Motifs [G02.111.570.820.709.275.750.500]

Protein Interaction Domains and Motifs

Ankyrin Repeat [G02.111.570.820.709.275.750.500.080]

Ankyrin Repeat

B30.2-SPRY Domain [G02.111.570.820.709.275.750.500.290]

B30.2-SPRY Domain

BTB-POZ Domain [G02.111.570.820.709.275.750.500.343]

BTB-POZ Domain

Death Domain Superfamily [G02.111.570.820.709.275.750.500.395]

Death Domain Superfamily

FERM Domains [G02.111.570.820.709.275.750.500.422]

FERM Domains

Kelch Repeat [G02.111.570.820.709.275.750.500.448]

Kelch Repeat

MYND Domains [G02.111.570.820.709.275.750.500.474]

MYND Domains

PDZ Domains [G02.111.570.820.709.275.750.500.500]

PDZ Domains

RING Finger Domains [G02.111.570.820.709.275.750.500.625]

RING Finger Domains

src Homology Domains [G02.111.570.820.709.275.750.500.750]

src Homology Domains

Sterile Alpha Motif [G02.111.570.820.709.275.750.500.813]

Sterile Alpha Motif

Tetratricopeptide Repeat [G02.111.570.820.709.275.750.500.829]

Tetratricopeptide Repeat

Tudor Domain [G02.111.570.820.709.275.750.500.844]

Tudor Domain

WD40 Repeats [G02.111.570.820.709.275.750.500.875]

WD40 Repeats

WW Domains [G02.111.570.820.709.275.750.500.937]

WW Domains

src Homology Domains - Preferred

Concept UI	M0028276
Scope note	Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
Preferred term	src Homology Domains
Entry term(s)	Homology Domain, src Homology Domains, src SH Domain SH Domains src Homology Domain

SH2 Domain - Narrower

Concept UI	M0028274
Preferred term	SH2 Domain
Entry term(s)	SH2 Domains src Homology Region 2 Domain

SH3 Domain - Narrower

Concept UI	M0028275
Preferred term	SH3 Domain
Entry term(s)	SH3 Domains

SH1 Domain - Narrower

Concept UI	M0028273
Preferred term	SH1 Domain
Entry term(s)	SH1 Domains

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