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Descriptor English: Nod2 Signaling Adaptor Protein
Descriptor Spanish: Proteína Adaptadora de Señalización NOD2
Descriptor proteína adaptadora de señalización NOD2
Entry term(s) proteína 2 de dominio de oligomerización de nucleótidos
proteína 2 del dominio de oligomerización de nucleótidos
Scope note: Proteína adaptadora señalizadora de NOD que contiene dos dominios C-terminales ricos en leucina que reconocen el PEPTIDOGLICANO BACTERIANO. Señala por medio de un dominio de reclutamiento N-terminal de caspasas que interactúa con otras PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN CARD tales como las SERINA-TREONINA CINASAS RIP. La proteína desempeña un papel en la respuesta defensiva del huésped al señalizar la activación de CASPASAS y del SISTEMA DE SEÑALIZACIÓN MAP CINASA. Las mutaciones del gen que codifica la proteína del dominio 2 de oligomerización nucleotídca se han asociado con una mayor susceptibilidad a la ENFERMEDAD DE CROHN.
Descriptor Portuguese: Proteína Adaptadora de Sinalização NOD2
Descriptor French: Protéine adaptatrice de signalisation NOD2
Entry term(s): CARD15 Protein
Caspase Recruitment Domain Protein 15
Nucleotide Oligomerization Domain 2 Protein
Tree number(s): D12.644.360.024.131.500
D12.644.360.024.313.500
D12.644.360.075.358.500
D12.644.360.539.500.500
D12.776.157.057.006.500
D12.776.157.057.078.500
D12.776.476.024.139.500
D12.776.476.024.391.500
D12.776.476.075.358.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053473
Scope note: A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (2001-2004)
Intracellular Signaling Peptides and Proteins (2005-2006)
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52307
Unique ID: D053473
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/03/30
Nod2 Signaling Adaptor Protein - Preferred
Concept UI M0493385
Scope note A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Preferred term Nod2 Signaling Adaptor Protein
Entry term(s) CARD15 Protein
Caspase Recruitment Domain Protein 15
Nucleotide Oligomerization Domain 2 Protein



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