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Descriptor English: NLR Proteins
Descriptor Spanish: Proteínas NLR
Descriptor proteínas NLR
Entry term(s) proteína NLR
proteína con dominio de repeticiones ricas en leucina y dominio de unión a nucleótidos
proteínas con dominio de unión a nucleótidos y repeticiones ricas en leucina
receptor de tipo NOD
receptores similares a NOD
Scope note: Proteínas señaladoras intracelulares definidas por la presencia de una región de unión a NUCLEÓTIDOS y de repeticiones ricas en LEUCINA. Su estructura general consta de una cualquiera de las variedades de dominios efectores en su N-terminal, como el dominio de reclutamiento de caspasa (CARD), el dominio central de unión a nucleótidos, y un número variable de repeticiones ricas en leucina C-terminales. Son importantes para el reconocimiento de los patógenos en la RESPUESTA INMUNITARIA INNATA de animales y plantas. Entre los miembros de la familia de proteínas NLR están las PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN NOD.
Descriptor Portuguese: Proteínas NLR
Descriptor French: Protéines NLR
Entry term(s): NLR Protein
NOD like Receptor
NOD like Receptors
NOD-like Receptor
NOD-like Receptors
Nucleotide Binding Domain Leucine Rich Repeat Protein
Nucleotide binding Domain Leucine rich Repeat Proteins
Nucleotide-Binding Domain Leucine-Rich Repeat Protein
Nucleotide-binding Domain Leucine-rich Repeat Proteins
Protein, NLR
Proteins, NLR
Receptor, NOD-like
Receptors, NOD-like
Tree number(s): D12.644.360.539
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070576
Scope note: Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nod Signaling Adaptor Proteins (2007-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56549
Unique ID: D000070576
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27
NLR Proteins - Preferred
Concept UI M000610980
Scope note Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
Preferred term NLR Proteins
Entry term(s) NLR Protein
NOD like Receptor
NOD like Receptors
NOD-like Receptor
NOD-like Receptors
Nucleotide Binding Domain Leucine Rich Repeat Protein
Nucleotide binding Domain Leucine rich Repeat Proteins
Nucleotide-Binding Domain Leucine-Rich Repeat Protein
Nucleotide-binding Domain Leucine-rich Repeat Proteins
Protein, NLR
Proteins, NLR
Receptor, NOD-like
Receptors, NOD-like



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