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Descriptor English: TNF Receptor-Associated Factor 4
Descriptor Spanish: Factor 4 Asociado a Receptor de TNF
Descriptor factor 4 asociado a receptores TNF
Entry term(s) TRAF4
Scope note: Miembro, ampliamente expresado, de la familia asociada al receptor de TNF que puede desempeñar un papel en el desarrollo neuronal y en la EMBRIOGÉNESIS. Aunque el factor 4 asociado al receptor de TNF no se asocia fuertemente con los RECEPTORES DEL FACTOR DE NECROSIS TUMORAL, puede ser un socio de señalización con la PROTEÍNA RELACIONADA CON TFNR INDUCIDA POR GLUCOCORTICOIDES que desempeña un papel en la activación de las PROTEÍNA CINASAS JNK ACTIVADAS POR MITÓGENOS y NF-KAPPA B.
Descriptor Portuguese: Fator 4 Associado a Receptor de TNF
Descriptor French: Facteur-4 associé aux récepteurs de TNF
Entry term(s): Cysteine Rich Domain Associated with RING and TRAF Domains Protein 1
Cysteine-Rich Domain Associated with RING and TRAF Domains Protein 1
TNF Receptor Associated Factor 4
TNF Receptor Associated Protein 4
TNF Receptor-Associated Protein 4
TRAF4
Tree number(s): D12.644.360.024.500.906
D12.776.157.057.500.906
D12.776.476.024.500.906
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053449
Scope note: A widely expressed member of the TNF receptor-associated family that may play a role in neuronal development and EMBRYOGENESIS. Although TNF receptor-associated factor 4 does not strongly associate with TUMOR NECROSIS FACTOR RECEPTORS it may be a signaling partner with the GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN that plays a role in the activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES and NF-KAPPA B.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2007: TNF RECEPTOR-ASSOCIATED FACTOR 4 was indexed under TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS 1995-2006
History Note: 2007(1995)
DeCS ID: 52316
Unique ID: D053449
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/11/24
TNF Receptor-Associated Factor 4 - Preferred
Concept UI M0253606
Scope note A widely expressed member of the TNF receptor-associated family that may play a role in neuronal development and EMBRYOGENESIS. Although TNF receptor-associated factor 4 does not strongly associate with TUMOR NECROSIS FACTOR RECEPTORS it may be a signaling partner with the GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN that plays a role in the activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES and NF-KAPPA B.
Preferred term TNF Receptor-Associated Factor 4
Entry term(s) Cysteine Rich Domain Associated with RING and TRAF Domains Protein 1
Cysteine-Rich Domain Associated with RING and TRAF Domains Protein 1
TNF Receptor Associated Factor 4
TNF Receptor Associated Protein 4
TNF Receptor-Associated Protein 4
TRAF4



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