| Descriptor English: | Receptors, Death Domain | ||||||
| Descriptor Spanish: |
Receptores de Muerte Celular
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| Descriptor Portuguese: | Receptores de Morte Celular | ||||||
| Descriptor French: | Récepteurs à domaine de mort | ||||||
| Entry term(s): |
DR Family Receptors Death Domain Receptors Death Receptor Death Receptors Receptor, Death Receptors, DR Family Receptors, Death Domain Family |
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| Tree number(s): |
D12.776.543.750.690 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D053218 | ||||||
| Scope note: | A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. |
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| Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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| Public MeSH Note: | 2007 |
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| History Note: | 2007 |
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| Entry Version: | RECEPT DEATH DOMAIN |
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| Related: |
Receptors, Tumor Necrosis Factor
MeSH | ||||||
| DeCS ID: | 52336 | ||||||
| Unique ID: | D053218 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2007/01/01 | ||||||
| Date of Entry: | 2006/07/05 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Receptors, Death Domain
- Preferred
| Concept UI |
M0492026 |
| Scope note | A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. |
| Preferred term | Receptors, Death Domain |
| Entry term(s) |
DR Family Receptors Death Domain Receptors Death Receptor Death Receptors Receptor, Death Receptors, DR Family Receptors, Death Domain Family |
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