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Descriptor English: Receptors, Notch
Descriptor Spanish: Receptores Notch
Descriptor receptores Notch
Entry term(s) proteína Notch
receptor Notch
Scope note: Familia de receptores de la superficie celular conservados que contienen repeticiones del FACTOR DE CRECIMIENTO EPIDÉRMICO en su dominio extracelular y REPETICIONES DE ANKIRINA en sus dominios citoplasmáticos. El dominio citoplasmático de los receptores Notch se libera tras la unión al ligando y se transloca al NÚCLEO CELULAR, donde actúa como factor de transcripción.
Descriptor Portuguese: Receptores Notch
Descriptor French: Récepteurs Notch
Entry term(s): Notch Protein
Notch Proteins
Notch Receptor
Notch Receptors
Protein, Notch
Receptor, Notch
Tree number(s): D12.776.543.750.725
D12.776.930.770
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051880
Scope note: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2006; RECEPTORS, NOTCH was indexed under MEMBRANE PROTEINS 1990-2005, & under INSECT HORMONES 1990-1995
History Note: 2006(1990)
DeCS ID: 51148
Unique ID: D051880
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/05/27
Receptors, Notch - Preferred
Concept UI M0176572
Scope note A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Preferred term Receptors, Notch
Entry term(s) Notch Protein
Notch Proteins
Notch Receptor
Notch Receptors
Protein, Notch
Receptor, Notch



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