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Descriptor English: Dual Specificity Phosphatase 2
Descriptor Spanish: Fosfatasa 2 de Especificidad Dual
Descriptor fosfatasa 2 de doble especificidad
Scope note: Subtipo de fosfatasa de doble especificidad que desempeña un papel en la transducción de señales intracelulares al inactivar a las PROTEÍNAS CINASAS ACTIVADAS POR MITÓGENOS. Tiene especificidad por las CINASAS MAP REGULADAS POR SEÑALES EXTRACELULARES y se encuentra principalmente en el NÚCLEO CELULAR.
Descriptor Portuguese: Fosfatase 2 de Especificidade Dupla
Descriptor French: Dual Specificity Phosphatase 2
Entry term(s): PAC 1 Phosphatase
PAC-1 Phosphatase
PAC1 Phosphatase
Phosphatase, PAC-1
Phosphatase, PAC1
Tree number(s): D08.811.277.352.650.587.250
D08.811.277.352.650.625.225.250
D08.811.277.352.650.775.250.250
D08.811.641.755.250
D12.776.476.445.250
D12.776.476.559.225.250
D12.776.476.564.250.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054641
Scope note: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CELL NUCLEUS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.48
Public MeSH Note: 2008; DUAL SPECIFICITY PHOSPHATASE 2 was indexed under PROTEIN TYROSINE PHOSPHATASES 1994-2007
History Note: 2008(1994)
DeCS ID: 52689
Unique ID: D054641
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/23
Dual Specificity Phosphatase 2 - Preferred
Concept UI M0227847
Scope note A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CELL NUCLEUS.
Preferred term Dual Specificity Phosphatase 2
Entry term(s) PAC 1 Phosphatase
PAC-1 Phosphatase
PAC1 Phosphatase
Phosphatase, PAC-1
Phosphatase, PAC1



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