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Descriptor English: Central Tolerance
Descriptor Spanish: Tolerancia Central
Descriptor tolerancia central
Scope note: El mecanismo en los órganos linfoides centrales (TIMO, MÉDULA ÓSEA) que previene que los linfocitos inmaduros reaccionen con AUTOANTÍGENOS. Se logra mediante ANERGIA CLONAL y SUPRESIÓN CLONAL.
Descriptor Portuguese: Tolerância Central
Descriptor French: Tolérance centrale
Entry term(s): Tolerance, Central
Tree number(s): G12.535.425.800.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D061167
Scope note: The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Immune Tolerance (1980-2011)
Self Tolerance (1998-2011)
Public MeSH Note: 2012
History Note: 2012
DeCS ID: 54818
Unique ID: D061167
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2016/06/16
Central Tolerance - Preferred
Concept UI M0556537
Scope note The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.
Preferred term Central Tolerance
Entry term(s) Tolerance, Central



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