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Descriptor English: NAV1.6 Voltage-Gated Sodium Channel
Descriptor Spanish: Canal de Sodio Activado por Voltaje NAV1.6
Descriptor canales del sodio dependientes de voltaje NAV1.6
Entry term(s) subunidad alfa tipo 8 de los canales del sodio dependientes de voltaje
Scope note: Subtipo de canal del sodio dependiente de voltaje, ampliamente expresado en las neuronas del sistema nervioso central y periférico. Defectos en el gen SCN8A, que codifica la subunidad alfa de este canal de sodio, están asociados con ATAXIA y déficits cognitivos.
Descriptor Portuguese: Canal de Sódio Disparado por Voltagem NAV1.6
Descriptor French: Canal sodique voltage-dépendant NAV1.6
Entry term(s): NAV1.6 Voltage Gated Sodium Channel
SCN8A Sodium Channel alpha Subunit
Type 8 Voltage Gated Sodium Channel
Type 8 Voltage-Gated Sodium Channel
Voltage Gated Sodium Channel Type 8
Voltage Gated Sodium Channel Type 8 Subunit alpha
Voltage-Gated Sodium Channel Type 8
Voltage-Gated Sodium Channel Type 8 Subunit alpha
Tree number(s): D12.776.157.530.400.875.750.600
D12.776.543.550.450.875.750.600
D12.776.543.585.400.875.750.600
D12.776.631.960.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D062557
Scope note: A voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Voltage-Gated Sodium Channel Blockers
agonists:Voltage-Gated Sodium Channel Agonists
Previous Indexing: Sodium Channels (1989-2012)
Public MeSH Note: 2013
History Note: 2013
DeCS ID: 54952
Unique ID: D062557
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/07/01
NAV1.6 Voltage-Gated Sodium Channel - Preferred
Concept UI M0568597
Scope note A voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits.
Preferred term NAV1.6 Voltage-Gated Sodium Channel
Entry term(s) NAV1.6 Voltage Gated Sodium Channel
Type 8 Voltage Gated Sodium Channel
Type 8 Voltage-Gated Sodium Channel
Voltage Gated Sodium Channel Type 8
Voltage-Gated Sodium Channel Type 8
Voltage-Gated Sodium Channel Type 8 Subunit alpha - Narrower
Concept UI M0568580
Preferred term Voltage-Gated Sodium Channel Type 8 Subunit alpha
Entry term(s) SCN8A Sodium Channel alpha Subunit
Voltage Gated Sodium Channel Type 8 Subunit alpha



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