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Descriptor English: NAV1.1 Voltage-Gated Sodium Channel
Descriptor Spanish: Canal de Sodio Activado por Voltaje NAV1.1
Descriptor canales del sodio dependientes de voltaje NAV1.1
Entry term(s) subunidad alfa tipo 1 de los canales del sodio dependientes de voltaje
Scope note: Subtipo de canal del sodio dependiente de voltaje, que se expresa predominantemente en el SISTEMA NERVIOSO CENTRAL. Defectos en el gen SCN1A, que codifica para la subunidad alfa de este canal de sodio, están asociados con el SÍNDROME DE DRAVET, epilepsia generalizada con convulsiones febriles plus, tipo 2 (GEFS+2), migraña hemipléjica familiar tipo 3.
Descriptor Portuguese: Canal de Sódio Disparado por Voltagem NAV1.1
Descriptor French: Canal sodique voltage-dépendant NAV1.1
Entry term(s): NAV1.1 Voltage Gated Sodium Channel
NAV1.1 alpha Subunit
SCN1A Sodium Channel alpha Subunit
Sodium Channel, Voltage-Gated, Type I, alpha Protein
Type 1 Voltage Gated Sodium Channel
Type 1 Voltage-Gated Sodium Channel
Voltage Gated Sodium Channel Type 1
Voltage Gated Sodium Channel Type 1 Subunit alpha
Voltage Gated Sodium Channel Type 1 alpha Subunit
Voltage-Gated Sodium Channel Type 1
Voltage-Gated Sodium Channel Type 1 Subunit alpha
Voltage-Gated Sodium Channel Type 1 alpha Subunit
alpha Subunit, NAV1.1
Tree number(s): D12.776.157.530.400.875.750.100
D12.776.543.550.450.875.750.100
D12.776.543.585.400.875.750.100
D12.776.631.960.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D062550
Scope note: A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Voltage-Gated Sodium Channel Blockers
agonists:Voltage-Gated Sodium Channel Agonists
Previous Indexing: Sodium Channels (1989-2012)
Public MeSH Note: 2013; SODIUM CHANNEL, VOLTAGE-GATED, TYPE I, ALPHA PROTEIN was indexed under SODIUM CHANNELS 2000-2012
History Note: 2013
Related: Epilepsies, Myoclonic MeSH
DeCS ID: 54947
Unique ID: D062550
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/07/01
NAV1.1 Voltage-Gated Sodium Channel - Preferred
Concept UI M0568583
Scope note A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
Preferred term NAV1.1 Voltage-Gated Sodium Channel
Entry term(s) NAV1.1 Voltage Gated Sodium Channel
Type 1 Voltage Gated Sodium Channel
Type 1 Voltage-Gated Sodium Channel
Voltage Gated Sodium Channel Type 1
Voltage-Gated Sodium Channel Type 1
Voltage-Gated Sodium Channel Type 1 Subunit alpha - Narrower
Concept UI M0568573
Preferred term Voltage-Gated Sodium Channel Type 1 Subunit alpha
Entry term(s) NAV1.1 alpha Subunit
SCN1A Sodium Channel alpha Subunit
Sodium Channel, Voltage-Gated, Type I, alpha Protein
Voltage Gated Sodium Channel Type 1 Subunit alpha
Voltage Gated Sodium Channel Type 1 alpha Subunit
Voltage-Gated Sodium Channel Type 1 alpha Subunit
alpha Subunit, NAV1.1



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