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Descriptor English: Claudin-1
Descriptor Spanish: Claudina-1
Descriptor claudina 1
Scope note: Proteína integral de la membrana localizada en las UNIONES ESTRECHAS donde interviene en el control de la permeabilidad paracelular de las células polarizadas. Las mutaciones del gen de la claudina-1 se asocian al síndrome de ictiosis-colangitis esclerosante neonatal (NISCH).
Descriptor Portuguese: Claudina-1
Descriptor French: Claudine-1
Entry term(s): Claudin 1
Tree number(s): D12.776.543.940.200.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D062445
Scope note: An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2013; CLAUDIN-1 was indexed under MEMBRANE PROTEINS 1998-2012
History Note: 2013
DeCS ID: 54977
Unique ID: D062445
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/01/15
Claudin-1 - Preferred
Concept UI M0568452
Scope note An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.
Preferred term Claudin-1
Entry term(s) Claudin 1



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