DeCS

Descriptor English:

Immunoreceptor Tyrosine-Based Activation Motif

Descriptor Spanish:

Motivo de Activación del Inmunorreceptor Basado en Tirosina

Spanish from Spain

Descriptor	motivo de activación de inmunorreceptores basado en tirosina
Entry term(s)	motivo ITAM motivo activador de inmunorreceptores dependiente de tirosina
Scope note:	SECUENCIA DE AMINOÁCIDOS conservada que se localiza en dominios intracelulares de una familia de proteínas transmembrana involucrada en diversas RESPUESTAS INMUNOLÓGICAS. La SECUENCIA DE CONSENSO de este motivo es YXXL(o I)X(6-8)YXXL(o I) (donde X puede ser cualquier aminoácido). Cuando motivos ITAM fosforilados disponen de puntos de acoplamiento para PROTEÍNA TIROSINA CINASAS de la familia Syk se forman complejos de señalización que llevan a la activación de respuestas inmunológicas.

Descriptor Portuguese:

Motivo de Ativação do Imunorreceptor Baseado em Tirosina

Descriptor French:

Motif d'activation de l'immunorécepteur dépendant de la tyrosine

Entry term(s):

Immune Receptor Tyrosine Based Activation Motif
Immune Receptor Tyrosine-Based Activation Motif
Immuno Receptor Tyrosine Based Activation Motif
Immuno-Receptor Tyrosine-Based Activation Motif
Immunoreceptor Tyrosine Based Activation Motif

Tree number(s):

G02.111.570.820.709.275.500.440

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D061625

Scope note:

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Public MeSH Note:

2013

History Note:

2013

DeCS ID:

55098

Unique ID:

D061625

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2013/01/01

Date of Entry:

2012/07/03

Revision Date:

2016/07/05

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Amino Acid Motifs [G02.111.570.820.709.275.500]

Amino Acid Motifs

Ankyrin Repeat [G02.111.570.820.709.275.500.030]

Ankyrin Repeat

AT-Hook Motifs [G02.111.570.820.709.275.500.050]

AT-Hook Motifs

Cystine Knot Motifs [G02.111.570.820.709.275.500.127]

Cystine Knot Motifs

F-Box Motifs [G02.111.570.820.709.275.500.205]

F-Box Motifs

Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]

Helix-Loop-Helix Motifs

Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]

Immunoreceptor Tyrosine-Based Activation Motif

Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]

Immunoreceptor Tyrosine-Based Inhibition Motif

Kazal Motifs [G02.111.570.820.709.275.500.490]

Kazal Motifs

Kelch Repeat [G02.111.570.820.709.275.500.500]

Kelch Repeat

Leucine Zippers [G02.111.570.820.709.275.500.520]

Leucine Zippers

Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]

Poly-ADP-Ribose Binding Motif

RNA-Binding Motifs [G02.111.570.820.709.275.500.869]

RNA-Binding Motifs

Sterile Alpha Motif [G02.111.570.820.709.275.500.898]

Sterile Alpha Motif

AAA Domain [G02.111.570.820.709.275.500.913]

AAA Domain

Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]

Tetratricopeptide Repeat

WD40 Repeats [G02.111.570.820.709.275.500.927]

WD40 Repeats

Zinc Fingers [G02.111.570.820.709.275.500.985]

Zinc Fingers

Immunoreceptor Tyrosine-Based Activation Motif - Preferred

Concept UI	M0559749
Scope note	A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.
Preferred term	Immunoreceptor Tyrosine-Based Activation Motif
Entry term(s)	Immune Receptor Tyrosine Based Activation Motif Immune Receptor Tyrosine-Based Activation Motif Immuno Receptor Tyrosine Based Activation Motif Immuno-Receptor Tyrosine-Based Activation Motif Immunoreceptor Tyrosine Based Activation Motif

We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.