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Descriptor English: Enhancer of Zeste Homolog 2 Protein
Descriptor Spanish: Proteína Potenciadora del Homólogo Zeste 2
Descriptor homólogo 2 del potenciador de zeste
Entry term(s) histona-lisina N-metiltransferasa EZH2
lisina N-metiltransferasa-6
potenciador de zeste homólogo 2
potenciador del homólogo zeste 2
proteína potenciadora del homólogo zeste 2
Scope note: Histona-lisina N-metiltransferasa y subunidad catalítica del complejo represor Polycomb 2. Metila la LISINA 9 (H3K9me) y la LISINA 27 (H3K27me) de la HISTONA H3, lo que ocasiona la represión transcripcional del gen diana afectado. EZH2 también metila proteínas no histónicas tales como el FACTOR DE TRANSCRIPCIÓN GATA4 y el receptor nuclear RORA. Regula los RELOJES CIRCADIANOS mediante la metilación de histonas de las REGIONES PROMOTORAS de los genes de proteínas circadianas, y su actividad represora también es importante para la identidad y diferenciación de las CÉLULAS MADRE EMBRIONARIAS.
Descriptor Portuguese: Proteína Potenciadora do Homólogo 2 de Zeste
Descriptor French: Protéine-2 homologue de l'activateur de Zeste
Entry term(s): EZH2, Histone-Lysine N-Methyltransferase
Enhancer of Zeste Homolog 2
Histone Lysine N Methyltransferase EZH2
Histone-Lysine N-Methyltransferase EZH2
Lysine N Methyltransferase 6
Lysine N-Methyltransferase-6
Tree number(s): D05.500.781.750.250
D08.811.913.555.500.800.200.500.500.500
D12.776.660.235.600.200.250
D12.776.664.235.800.200.250
D12.776.930.780.890.200.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071221
Scope note: A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.1.1.43
Public MeSH Note: 2017; ENHANCER OF ZESTE HOMOLOG 2 was indexed under POLYCOMB REPRESSIVE COMPLEX 2 2013-2016, under DNA-BINDING PROTEINS and TRANSCRIPTION FACTORS 2005-2012, and under PROTEINS 2005
History Note: 2017 (2005)
DeCS ID: 56434
Unique ID: D000071221
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2018/06/19
Enhancer of Zeste Homolog 2 Protein - Preferred
Concept UI M000613664
Scope note A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
Preferred term Enhancer of Zeste Homolog 2 Protein
Entry term(s) EZH2, Histone-Lysine N-Methyltransferase
Enhancer of Zeste Homolog 2
Histone Lysine N Methyltransferase EZH2
Histone-Lysine N-Methyltransferase EZH2
Lysine N Methyltransferase 6
Lysine N-Methyltransferase-6



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