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Descriptor English: Protein Phosphatase 2C
Descriptor Spanish: Proteína Fosfatasa 2C
Descriptor proteína fosfatasa 2C
Entry term(s) PP2 beta
PP2C épsilon
PP2Cgamma
PP2Cépsilon
fosfatasa PPM1D
fosfatasa Ppm1b
fosfatasa Ptc2
proteína fosfatasa 2C beta
proteína fosfatasa 2C delta
proteína fosfatasa 2C gamma
proteína fosfatasa 2C épsilon
proteína fosfatasa dependiente de magnesio 1D, isoforma delta
proteína fosfatasa dependiente de magnesio 2C beta
proteína fosfatasas PPM1
proteína fosfatasas dependientes de magnesio 1D, isoforma delta
proteína fosfatasas dependientes de magnesio PPM1
Scope note: Una de las cuatro clases de serina-treonina proteína fosfatasas específicas. La proteína fosfatasa 2C es una enzima monomérica de un tamaño aproximado de 42 kDa. Tiene una amplia especificidad de sustratos dependiente de cationes divalentes (principalmente manganeso y magnesio). Se conocen tres isoenzimas en mamíferos: PP2C-alfa, beta y gamma. En levaduras existen cuatro homólogos de PP2C: fosfatasa PTC1 que tiene una actividad tirosina fosfatasa débil, fosfatasa PTC2, fosfatasa PTC3 y PCT4. Las isoenzimas de PP2C también se dan en Arabidopsis thaliana en la que la proteína fosfatasa asociada a la quinasa (KAPP), que contiene un dominio C-terminal PP2C, desfosforila la quinasa RLK5 Ser-Thr similar a receptor.
Descriptor Portuguese: Proteína Fosfatase 2C
Descriptor French: Protein phosphatase 2C
Entry term(s): 2C, Protein Phosphatase
Magnesium Dependent Protein Phosphatase 2C beta
Magnesium-Dependent Protein Phosphatase 2C beta
PP2C beta
PP2Cepsilon
PP2Cgamma
PPM1 Magnesium Dependent Protein Phosphatases
PPM1 Magnesium-Dependent Protein Phosphatases
PPM1 Protein Phosphatases
PPM1D Phosphatase
PPM1E Phosphatase
PPM1G Phosphatase
Phosphatase 2C, Protein
Phosphatase, PPM1D
Phosphatase, PPM1E
Phosphatase, PPM1G
Phosphatase, Ppm1b
Phosphatase, Ptc2
Phosphatases, PPM1 Protein
Ppm1b Phosphatase
Protein Phosphatase 1D Magnesium Dependent, delta isoform
Protein Phosphatase 1D Magnesium-Dependent, delta isoform
Protein Phosphatase 2C beta
Protein Phosphatase 2C delta
Protein Phosphatase 2C epsilon
Protein Phosphatase 2C gamma
Protein Phosphatases, PPM1
Ptc2 Phosphatase
beta, PP2C
Tree number(s): D08.811.277.352.650.625.716
D12.776.476.559.716
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071636
Scope note: One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.16
Public MeSH Note: 2017; PROTEIN PHOSPHATASE 2C was indexed under PHOSPHOPROTEIN PHOSPHATASES 1993-2016
History Note: 2017 (2016)
DeCS ID: 56478
Unique ID: D000071636
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/26
Protein Phosphatase 2C - Preferred
Concept UI M0220268
Scope note One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Preferred term Protein Phosphatase 2C
Entry term(s) 2C, Protein Phosphatase
PPM1 Magnesium Dependent Protein Phosphatases
PPM1 Magnesium-Dependent Protein Phosphatases
PPM1 Protein Phosphatases
Phosphatase 2C, Protein
Phosphatase, Ptc2
Phosphatases, PPM1 Protein
Protein Phosphatases, PPM1
Ptc2 Phosphatase
Protein Phosphatase 2C epsilon - Narrower
Concept UI M0449435
Preferred term Protein Phosphatase 2C epsilon
Entry term(s) PP2Cepsilon
PPM1E Phosphatase
Phosphatase, PPM1E
Protein Phosphatase 2C beta - Narrower
Concept UI M0220263
Preferred term Protein Phosphatase 2C beta
Entry term(s) PP2C beta
Phosphatase, Ppm1b
Ppm1b Phosphatase
beta, PP2C
Protein Phosphatase 2C delta - Narrower
Concept UI M0497033
Preferred term Protein Phosphatase 2C delta
Entry term(s) PPM1D Phosphatase
Phosphatase, PPM1D
Protein Phosphatase 1D Magnesium Dependent, delta isoform
Protein Phosphatase 1D Magnesium-Dependent, delta isoform
Protein Phosphatase 2C gamma - Narrower
Concept UI M0220264
Preferred term Protein Phosphatase 2C gamma
Entry term(s) PP2Cgamma
PPM1G Phosphatase
Phosphatase, PPM1G
Magnesium-Dependent Protein Phosphatase 2C beta - Narrower
Concept UI M0225719
Preferred term Magnesium-Dependent Protein Phosphatase 2C beta
Entry term(s) Magnesium Dependent Protein Phosphatase 2C beta



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