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Descriptor English: Perilipins
Descriptor Spanish: Perilipinas
Descriptor perilipinas
Entry term(s) proteínas PAT
proteínas PLIN
proteínas de la familia de las perilipinas
proteínas perilipina, adipofilina y TIP47
proteínas perilipinas
Scope note: Familia de proteínas asociadas a las gotas lipídicas en vertebrados e insectos. Constan de un dominio PAT N-terminal conservado (una región en alfa-hélice de unos 110 aminoácidos), una región de repeticiones de 11 aminoácidos y regiones hidrofóbicas de unión a lípidos o haces de 4 hélices cerca del extremo C-terminal. Las perilipinas se localizan de forma transitoria o constitutiva en las GOTAS LIPÍDICAS de los ADIPOCITOS y CÉLULAS ESPUMOSAS, especialmente en regiones adyacentes a la MEMBRANA PLASMÁTICA y al RETÍCULO ENDOPLÁSMICO. Son críticas para la síntesis y la homeostasis de las gotas lipídicas así como para la regulación del metabolismo lipídico. Las variaciones genéticas en las perilipinas se asocian a la ATEROSCLEROSIS, la OBESIDAD y la DIABETES MELLITUS.
Descriptor Portuguese: Perilipinas
Descriptor French: Périlipines
Entry term(s): PAT Proteins
PLIN Proteins
Perilipin Adipophilin TIP47 Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Proteins, PAT
Proteins, PLIN
Proteins, Perilipin
Proteins, Perilipin-Adipophilin-TIP47
Tree number(s): D12.776.157.464.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070137
Scope note: A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (1991-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56570
Unique ID: D000070137
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/01/19
Perilipins - Preferred
Concept UI M000609416
Scope note A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Preferred term Perilipins
Entry term(s) PAT Proteins
PLIN Proteins
Perilipin Adipophilin TIP47 Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Proteins, PAT
Proteins, PLIN
Proteins, Perilipin
Proteins, Perilipin-Adipophilin-TIP47



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