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Descriptor English: Perilipin-2
Descriptor Spanish: Perilipina-2
Descriptor perilipina 2
Entry term(s) adipofilina
proteína ADRP
proteína PLIN2
proteína perilipina 2
proteína relacionada con la diferenciación adiposa
Scope note: Perilipina expresada por muchos tipos de células. Une ÁCIDOS GRASOS y COLESTEROL, estabiliza TRIGLICÉRIDOS y se localiza tanto en la superficie como en el núcleo hidrofóbico de las GOTAS LIPÍDICAS, así como en el RETÍCULO ENDOPLÁSMICO y la MEMBRANA PLASMÁTICA de los MACRÓFAGOS. También juega un papel central en la biogénesis de las GOTAS LIPÍDICAS y las CÉLULAS ESPUMOSAS y su expresión por los macrófagos está muy aumentada en las lesiones ateroscleróticas de las arterias humanas, junto con los marcadores de INFLAMACIÓN TNF-ALFA, RECEPTOR MCP-1 e IL-6.
Descriptor Portuguese: Perilipina-2
Descriptor French: Périlipine-2
Entry term(s): ADRP Protein
Adipophilin
Adipose Differentiation Related Protein
Adipose Differentiation-Related Protein
PLIN2 Protein
Perilipin 2
Perilipin 2 Protein
Protein, Adipose Differentiation-Related
Protein, PLIN2
Protein, Perilipin 2
Tree number(s): D12.776.157.464.500.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070780
Scope note: A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL, stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; PERILIPIN-2 was indexed under PEPTIDES 1998-2011; and under MEMBRANE PROTEINS 2011-2016
History Note: 2017 (1998)
DeCS ID: 56572
Unique ID: D000070780
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/01/19
Perilipin-2 - Preferred
Concept UI M0298231
Scope note A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL, stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.
Preferred term Perilipin-2
Entry term(s) ADRP Protein
Adipophilin
Adipose Differentiation Related Protein
Adipose Differentiation-Related Protein
PLIN2 Protein
Perilipin 2
Perilipin 2 Protein
Protein, Adipose Differentiation-Related
Protein, PLIN2
Protein, Perilipin 2



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