| Descriptor English: | Transcription Factor HES-1 | ||||||
| Descriptor Spanish: |
Factor de Transcripción HES-1
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| Descriptor Portuguese: | Fatores de Transcrição HES-1 | ||||||
| Descriptor French: | Facteur de transcription HES-1 | ||||||
| Entry term(s): |
HES-1, Transcription Factor Hairy Like Transcription Factor Hairy and Enhancer of Split 1 Protein Hairy-Like Transcription Factor Transcription Factor HES 1 Transcription Factor, Hairy-Like |
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| Tree number(s): |
D12.776.260.103.844 D12.776.930.125.844 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000072056 | ||||||
| Scope note: | A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Basic Helix-Loop-Helix Transcription Factors (1994-2016) Homeodomain Proteins (1994-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56597 | ||||||
| Unique ID: | D000072056 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Transcription Factor HES-1
- Preferred
| Concept UI |
M000616269 |
| Scope note | A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE. |
| Preferred term | Transcription Factor HES-1 |
| Entry term(s) |
HES-1, Transcription Factor Hairy Like Transcription Factor Hairy and Enhancer of Split 1 Protein Hairy-Like Transcription Factor Transcription Factor HES 1 Transcription Factor, Hairy-Like |
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