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Descriptor English: T-Cell Acute Lymphocytic Leukemia Protein 1
Descriptor Spanish: Proteína 1 de la Leucemia Linfocítica T Aguda
Descriptor proteína 1 de la leucemia linfocítica T aguda
Entry term(s) factor de transcripción TAL1
proteína TAL-1
Scope note: Factor de transcripción de estructura hélice-bucle-hélice básica que tiene un papel crítico en la HEMATOPOYESIS como regulador positivo de la diferenciación de las CÉLULAS ERITROIDES. Las translocaciones que afectan al gen TAL-1 se asocian a LEUCEMIA LINFOCÍTICA T AGUDA.
Descriptor Portuguese: Proteína 1 de Leucemia Linfocítica Aguda de Células T
Descriptor French: Protéine-1 de la lleucémie lymphoïde aiguë à cellules T
Entry term(s): T Cell Acute Lymphocytic Leukemia Protein 1
TAL 1 Protein
TAL-1 Protein
TAL1 Transcription Factor
Transcription Factor, TAL1
Tree number(s): D12.776.260.103.829
D12.776.624.664.700.960
D12.776.930.125.829
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073942
Scope note: A basic helix-loop-helix transcription factor that plays a critical role in HEMATOPOIESIS and as a positive regulator in the differentiation of ERYTHROID CELLS. Chromosome translocations involving the TAL-1 gene are associated with T-CELL ACUTE LYMPHOCYTIC LEUKEMIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Basic Helix-Loop-Helix Transcription Factors (2005-2017)
Proto-Oncogene Proteins (2005-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57106
Unique ID: D000073942
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
T-Cell Acute Lymphocytic Leukemia Protein 1 - Preferred
Concept UI M000625040
Scope note A basic helix-loop-helix transcription factor that plays a critical role in HEMATOPOIESIS and as a positive regulator in the differentiation of ERYTHROID CELLS. Chromosome translocations involving the TAL-1 gene are associated with T-CELL ACUTE LYMPHOCYTIC LEUKEMIA.
Preferred term T-Cell Acute Lymphocytic Leukemia Protein 1
Entry term(s) T Cell Acute Lymphocytic Leukemia Protein 1
TAL 1 Protein
TAL-1 Protein
TAL1 Transcription Factor
Transcription Factor, TAL1



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