Search
Descriptor English: Discoidin Domain
Descriptor Spanish: Dominio Discoidina
Descriptor dominio discoidina
Scope note: Dominio proteico originalmente identificado en las DISCOIDINAS. Está presente en un conjunto de proteínas no relacionadas entre sí de los organismos multicelulares, donde reconocen diferentes ligandos con funciones celulares características. Estructuralmente consisten en dos láminas beta antiparalelas que forman una configuración en "rollo de gelatina" estabilizada por dos uniones intramoleculares disulfuro. Las diferencias de secuencia dentro de este módulo determinan la especificidad de ligando; en los RECEPTORES DEL DOMINIO DISCOIDINA se une al COLÁGENO FIBRILAR y al COLÁGENO NO FIBRILAR.
Descriptor Portuguese: Domínio Discoidina
Descriptor French: Domaine discoïdine
Entry term(s): Discoidin Domains
Domain, Discoidin
Domains, Discoidin
Tree number(s): G02.111.570.820.709.275.750.219
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070822
Scope note: A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a "jellyroll" configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Lectins (1998-2016)
Protein Structure, Tertiary (1998-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56738
Unique ID: D000070822
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/09
Discoidin Domain - Preferred
Concept UI M000612305
Scope note A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a "jellyroll" configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.
Preferred term Discoidin Domain
Entry term(s) Discoidin Domains
Domain, Discoidin
Domains, Discoidin



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey