| Descriptor English: | Pleckstrin Homology Domains | ||||||
| Descriptor Spanish: |
Dominios Homólogos a Pleckstrina
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| Descriptor Portuguese: | Domínios de Homologia à Plecstrina | ||||||
| Descriptor French: | Domaines homologues de la pleckstrine | ||||||
| Entry term(s): |
Domain, PH Domain, Pleckstrin Homology Domains, PH Domains, Pleckstrin Homology Homology Domain, Pleckstrin Homology Domains, Pleckstrin PH Domain PH Domains Pleckstrin Homology Domain |
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| Tree number(s): |
G02.111.570.820.709.275.750.469 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000070539 | ||||||
| Scope note: | Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS. |
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| Allowable Qualifiers: |
DE drug effects GE genetics IM immunology PH physiology RE radiation effects |
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| Previous Indexing: |
Protein Structure, Tertiary (1994-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56742 | ||||||
| Unique ID: | D000070539 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/05/09 |
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PHENOMENA AND PROCESSES
Chemical Phenomena [G02]Chemical Phenomena
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Pleckstrin Homology Domains
- Preferred
| Concept UI |
M000610823 |
| Scope note | Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS. |
| Preferred term | Pleckstrin Homology Domains |
| Entry term(s) |
Domain, PH Domain, Pleckstrin Homology Domains, PH Domains, Pleckstrin Homology Homology Domain, Pleckstrin Homology Domains, Pleckstrin PH Domain PH Domains Pleckstrin Homology Domain |
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