DeCS

Descriptor English:

Methyl CpG Binding Domain

Descriptor Spanish:

Dominio de Unión a CpG-Metil

Spanish from Spain

Descriptor	dominio de unión a metil-CpG
Entry term(s)	dominio de unión a metil-CpG ADN
Scope note:	Dominio proteico de aproximadamente 70 aminoácidos de longitud que se pliega en una estructura sándwich formada por una hoja beta, una hélice alfa y un bucle C-terminal en horquilla, que forma un parche de unión hidrofóbico con el metil-ADN. Se une a las ISLAS DE CPG en los eucariotas y está presente en otros dominios de unión a CROMATINA y ADN como las SECUENCIAS AT-HOOK de las PROTEÍNAS DE UNIÓN AL ADN de las células eucariotas.

Descriptor Portuguese:

Domínio de Ligação a CpG Metilada

Descriptor French:

Domaine de liaison aux méthyl-CpG

Entry term(s):

Methyl CpG DNA Binding Domain

Tree number(s):

G02.111.570.820.709.275.750.438

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000070593

Scope note:

A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

DNA-Binding Proteins (1993-2016)

Public MeSH Note:

2017

History Note:

2017

DNA Methylation MeSH

DeCS ID:

56741

Unique ID:

D000070593

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2017/01/01

Date of Entry:

2016/07/08

Revision Date:

2016/07/05

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Protein Domains [G02.111.570.820.709.275.750]

Protein Domains

C2 Domains [G02.111.570.820.709.275.750.125]

C2 Domains

Carbohydrate Binding Modules [G02.111.570.820.709.275.750.157]

Carbohydrate Binding Modules

Catalytic Domain [G02.111.570.820.709.275.750.188]

Catalytic Domain

Discoidin Domain [G02.111.570.820.709.275.750.219]

Discoidin Domain

HMG-Box Domains [G02.111.570.820.709.275.750.235]

HMG-Box Domains

Immunoglobulin Domains [G02.111.570.820.709.275.750.250]

Immunoglobulin Domains

Kringles [G02.111.570.820.709.275.750.375]

Kringles

Methyl CpG Binding Domain [G02.111.570.820.709.275.750.438]

Methyl CpG Binding Domain

Pleckstrin Homology Domains [G02.111.570.820.709.275.750.469]

Pleckstrin Homology Domains

PR-SET Domains [G02.111.570.820.709.275.750.477]

PR-SET Domains

Proline-Rich Protein Domains [G02.111.570.820.709.275.750.485]

Proline-Rich Protein Domains

Protein Interaction Domains and Motifs [G02.111.570.820.709.275.750.500]

Protein Interaction Domains and Motifs

Methyl CpG Binding Domain - Preferred

Concept UI	M000611074
Scope note	A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.
Preferred term	Methyl CpG Binding Domain
Entry term(s)	Methyl CpG DNA Binding Domain

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