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Descriptor English: Baculoviral IAP Repeat-Containing 3 Protein
Descriptor Spanish: Proteína 3 que Contiene Repeticiones IAP de Baculovirus
Descriptor proteína 3 que contiene repeticiones IAP de baculovirus
Entry term(s) inhibidor de la apoptosis 2
inhibidor de la apoptosis celular-2
proteína 1 inhibidora de la apoptosis
proteína BIRC3
proteína Hiap-1
proteína IAP1
proteína c-IAP2
proteína cIAP2
proteína inhibidora de la apoptosis 1
Scope note: Regulador de la APOPTOSIS que funciona como una proteína ubiquitina ligasa E3. Contiene tres repeticiones baculovirales IAP en su mitad N-terminal, un DOMINIO CARD (dominio de reclutamiento y activación de caspasas) y un dominio RING finger en el extremo C. Se expresa ampliamente en los pulmones y riñones fetales y en los tejidos linfáticos adultos como el bazo, el timo y los linfocitos de la sangre. Actúa en la señalización de la INFLAMACIÓN, en la INMUNIDAD INNATA, el crecimiento y proliferación celular y en las metástasis cancerosas.
Descriptor Portuguese: Proteína 3 com Repetições IAP de Baculovírus
Descriptor French: Protéine-3 contenant des répétitions IAP baculovirales
Entry term(s): Apoptosis Inhibitor 2
Apoptosis-2 Cellular Inhibitor
BIRC3 Protein
Baculoviral IAP Repeat Containing 3 Protein
Baculoviral IAP Repeat Containing Protein 3
Cellular Inhibitor of Apoptosis 2
Cellular Inhibitor of Apoptosis-2
Hiap 1 Protein
Hiap-1 Protein
IAP1 Protein
Inhibitor 2, Apoptosis
Inhibitor of Apoptosis 1 Protein
Inhibitor of Apoptosis Protein 1
c-IAP2 Protein
cIAP2 Protein
Tree number(s): D08.811.464.938.750.210.250
D12.644.360.075.437.250
D12.776.476.075.437.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075747
Scope note: A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Caspase Inhibitors
Registry Number: EC 2.3.2.27
Previous Indexing: Inhibitor of Apoptosis Proteins (2006-2017)
Ubiquitin-Protein Ligases (2006-2017)
Public MeSH Note: 2018; for INHIBITOR OF APOPTOSIS 1 PROTEIN see INHIBITOR OF OF APOPTOSIS PROTEINS 2006-2017
History Note: 2018; for INHIBITOR OF APOPTOSIS 1 PROTEIN use INHIBITOR OF OF APOPTOSIS PROTEINS 2006-2017
DeCS ID: 57011
Unique ID: D000075747
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Baculoviral IAP Repeat-Containing 3 Protein - Preferred
Concept UI M000631361
Scope note A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.
Preferred term Baculoviral IAP Repeat-Containing 3 Protein
Entry term(s) Apoptosis Inhibitor 2
Apoptosis-2 Cellular Inhibitor
BIRC3 Protein
Baculoviral IAP Repeat Containing 3 Protein
Baculoviral IAP Repeat Containing Protein 3
Cellular Inhibitor of Apoptosis 2
Cellular Inhibitor of Apoptosis-2
Hiap 1 Protein
Hiap-1 Protein
IAP1 Protein
Inhibitor 2, Apoptosis
Inhibitor of Apoptosis 1 Protein
Inhibitor of Apoptosis Protein 1
c-IAP2 Protein
cIAP2 Protein



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