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Descriptor English: Aldo-Keto Reductase Family 1 Member C3
Descriptor Spanish: Miembro C3 de la Familia 1 de las Aldo-Ceto Reductasas
Descriptor miembro C3 de la familia 1 de las aldo-ceto reductasas
Entry term(s) 17-beta-hidroxiesteroide deshidrogenasa tipo 5
dihidrodiol deshidrogenasa 3
proteína AKR1C3
Scope note: Aldo-ceto reductasa que funciona como 17-BETA, 20 ALFA-HIDROXIESTEROIDE DESHIDROGENASA bidireccional. Cataliza la reducción de PROSTAGLANDINA D2 y PROSTAGLANDINA H2, así como la oxidación de 9alfa, 11beta-PGF2 a prostaglandina D2. También puede interconvertir estrógenos, ANDRÓGENOS y PROGESTINAS entre sus formas activas y sus metabolitos inactivos.
Descriptor Portuguese: Membro C3 da Família 1 de alfa-Ceto Redutase
Descriptor French: Aldo-keto reductase family 1 member C3
Entry term(s): 17 beta Hydroxysteroid Dehydrogenase Type 5
17-beta-Hydroxysteroid Dehydrogenase Type 5
AKR1C3 Protein
Aldo Keto Reductase Family 1 Member C3
Dihydrodiol Dehydrogenase 3
Tree number(s): D08.811.682.047.150.700.156.875
D08.811.682.047.436.375.140
D08.811.682.047.820.284.937
D08.811.682.047.820.375.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074425
Scope note: Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.1.1.357
Previous Indexing: 3-Hydroxysteroid Dehydrogenases (2004-2017)
Hydroxyprostaglandin Dehydrogenases (2004-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57018
Unique ID: D000074425
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05
Aldo-Keto Reductase Family 1 Member C3 - Preferred
Concept UI M000626540
Scope note Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.
Preferred term Aldo-Keto Reductase Family 1 Member C3
Entry term(s) 17 beta Hydroxysteroid Dehydrogenase Type 5
17-beta-Hydroxysteroid Dehydrogenase Type 5
AKR1C3 Protein
Aldo Keto Reductase Family 1 Member C3
Dihydrodiol Dehydrogenase 3



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