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Descriptor English: Aldo-Keto Reductases
Descriptor Spanish: Aldo-Ceto Reductasas
Descriptor aldo-ceto reductasas
Entry term(s) aldo-ceto reductasa
familia aldo-ceto reductasa
superfamilia aldo-ceto reductasa
Scope note: Familia de oxidorreductasas dependientes de NADPH que reducen sustratos carbonilo como los grupos aldehído de azúcares, CETOSTEROIDES, cetoprostaglandinas y QUINONAS. Son monómeros de unos 37 KDa y se caracterizan por una estructura paralela beta-8 (LÁMINA BETA)-alfa 8 (HÉLICES ALFA) en barril, que contiene el sitio de unión a NADP. Esta conformación favorece a los sustratos aromáticos y apolares.
Descriptor Portuguese: Aldo-Ceto Redutases
Descriptor French: Aldo-keto reductases
Entry term(s): Aldo Keto Reductase
Aldo Keto Reductase Family
Aldo Keto Reductase Superfamily
Aldo Keto Reductases
Aldo-Keto Reductase
Aldo-Keto Reductase Family
Aldo-Keto Reductase Superfamily
Reductase, Aldo-Keto
Reductases, Aldo-Keto
Tree number(s): D08.811.682.047.150.700.156
D08.811.682.047.820.284
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074408
Scope note: A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.1.1.-
Previous Indexing: Aldehyde Reductase (1976-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57015
Unique ID: D000074408
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/06
Aldo-Keto Reductases - Preferred
Concept UI M000626517
Scope note A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
Preferred term Aldo-Keto Reductases
Entry term(s) Aldo Keto Reductase Family
Aldo Keto Reductase Superfamily
Aldo Keto Reductases
Aldo-Keto Reductase Family
Aldo-Keto Reductase Superfamily
Reductases, Aldo-Keto
Aldo-Keto Reductase - Narrower
Concept UI M000628345
Preferred term Aldo-Keto Reductase
Entry term(s) Aldo Keto Reductase
Reductase, Aldo-Keto



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