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Descriptor English: Peroxisomal Multifunctional Protein-2
Descriptor Spanish: Proteína-2 Multifuncional Peroxisomal
Descriptor proteína multifuncional peroxisómica 2
Scope note: Proteína dimérica que se encuentra en los peroxisomas del hígado y tiene un importante papel en el metabolismo de los ÁCIDOS GRASOS y esteroides. El dímero se forma por escisión de un precursor proteico único y contiene un dominio enoil-CoA hidratasa-2 y un segundo dominio con actividades (S)-3-hidroxiacil-CoA deshidrogenasa y 17-beta-estradiol deshidrogenasa. La enzima es estereoespecífica en relación con la disposición de los dobles enlaces del sustrato y la posición del grupo 3-hidroxi de la reacción intermedia. Es complementada por la ENZIMA BIFUNCIONAL PEROXISÓMICA, que tiene la estereoespecificidad opuesta.
Descriptor Portuguese: Proteína Multifuncional do Peroxissomo-2
Descriptor French: Protéine-2 multifonctionnelle péroxysomique
Entry term(s): 17 beta Hydroxysteroid Dehydrogenase 4
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
4, 17-beta-Hydroxysteroid Dehydrogenase
Dehydrogenase 4, 17-beta-Hydroxysteroid
Multifunctional Protein-2, Peroxisomal
Peroxisomal Multifunctional Enzyme Type 2
Peroxisomal Multifunctional Protein 2
Tree number(s): D08.811.520.241.300.275.500
D08.811.641.812
D08.811.682.047.436.375.640
D08.811.682.047.820.150.926
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064029
Scope note: A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.2.1.107
Previous Indexing: 17-Hydroxysteroid Dehydrogenases (1997-2013)
Enoyl-CoA Hydratase (1997-2013)
Public MeSH Note: 2014
History Note: 2014
DeCS ID: 55288
Unique ID: D064029
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Peroxisomal Multifunctional Protein-2 - Preferred
Concept UI M0579232
Scope note A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Preferred term Peroxisomal Multifunctional Protein-2
Entry term(s) 17 beta Hydroxysteroid Dehydrogenase 4
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
4, 17-beta-Hydroxysteroid Dehydrogenase
Dehydrogenase 4, 17-beta-Hydroxysteroid
Multifunctional Protein-2, Peroxisomal
Peroxisomal Multifunctional Enzyme Type 2
Peroxisomal Multifunctional Protein 2



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