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Descriptor English: Serine Peptidase Inhibitor Kazal-Type 5
Descriptor Spanish: Inhibidor de Serinpeptidasas Tipo Kazal-5
Descriptor inhibidor de serinpeptidasas tipo Kazal-5
Entry term(s) Proteína LEKTI
inhibidor de serina proteasa tipo Kazal 5
inhibidor linfoepitelial tipo Kazal
proteína SPINK5
Scope note: Inhibidor de las serina peptidasas segregado que consta de 15 MOTIVOS KAZAL e inhibe las CALICREÍNAS KLK5, KLK7 y KLK14 así como la TRIPSINA. Juega importantes papeles en la protección de las MUCOSAS frente a la infección e inflamación y en el mantenimiento de la integridad de la piel. Las mutaciones del gen SPINK5 se asocian al SÍNDROME DE NETHERTON.
Descriptor Portuguese: Inibidor de Serinopeptidase do Tipo Kazal 5
Descriptor French: Inhibiteur de sérine peptidase de type Kazal-5
Entry term(s): Inhibitor, Lympho-Epithelial Kazal-Type
Kazal-Type Inhibitor, Lympho-Epithelial
LEKTI Protein
Lympho Epithelial Kazal Type Inhibitor
Lympho-Epithelial Kazal-Type Inhibitor
SPINK5 Protein
Serine Peptidase Inhibitor Kazal Type 5
Serine Protease Inhibitor Kazal Type 5
Serine Protease Inhibitor Kazal-Type 5
Tree number(s): D12.644.822.750.250
D12.776.815.688.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074163
Scope note: A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (1999-2017)
Proteinase Inhibitory Proteins, Secretory (2005-2017)
Public MeSH Note: 2018
History Note: 2018
Related: Kazal Motifs MeSH
Netherton Syndrome MeSH
DeCS ID: 57063
Unique ID: D000074163
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/24
Serine Peptidase Inhibitor Kazal-Type 5 - Preferred
Concept UI M000625733
Scope note A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
Preferred term Serine Peptidase Inhibitor Kazal-Type 5
Entry term(s) Inhibitor, Lympho-Epithelial Kazal-Type
Kazal-Type Inhibitor, Lympho-Epithelial
LEKTI Protein
Lympho Epithelial Kazal Type Inhibitor
Lympho-Epithelial Kazal-Type Inhibitor
SPINK5 Protein
Serine Peptidase Inhibitor Kazal Type 5
Serine Protease Inhibitor Kazal Type 5
Serine Protease Inhibitor Kazal-Type 5



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