| Descriptor English: | Trypsin Inhibitor, Kazal Pancreatic | ||||||
| Descriptor Spanish: |
Inhibidor de Tripsina Pancreática de Kazal
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| Descriptor Portuguese: | Inibidor da Tripsina Pancreática de Kazal | ||||||
| Descriptor French: | Inhibiteur de la trypsine pancréatique Kazal | ||||||
| Entry term(s): |
Acidic Pancreatic Trypsin Inhibitor Inhibitor, Tumor-Associated Trypsin Kazal Pancreatic Trypsin Inhibitor Pancreatic Secretory Trypsin Inhibitor Pancreatic Secretory Trypsin Inhibitor, Kazal Pancreatic Trypsin Secretory Inhibitor, Kazal SPINK1 Serine Peptidase Inhibitor, Kazal Type 1 Serine Peptidase Inhibitor, Kazal-Type 1 Serine Protease Inhibitor Kazal Type 1 Serine Protease Inhibitor Kazal-Type 1 Trypsin Inhibitor Kazal Pancreatic Trypsin Inhibitor, Pancreatic Secretory Trypsin Inhibitor, Tumor Associated Trypsin Inhibitor, Tumor-Associated Tumor Associated Trypsin Inhibitor Tumor-Associated Trypsin Inhibitor |
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| Tree number(s): |
D12.644.822.750.500 D12.776.124.050.850 D12.776.815.688.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D014359 | ||||||
| Scope note: | A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | 50936-63-5 | ||||||
| CAS Type 1 Name: | Trypsin inhibitor, pancreatic secretory | ||||||
| Previous Indexing: |
Pancreatic Juice (1972-1974) Trypsin Inhibitors (1972-1974) |
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| Public MeSH Note: | 91; was see under TRYPSIN INHIBITORS 1975-90 |
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| History Note: | 91(75); was see under TRYPSIN INHIBITORS 1975-90 |
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| Entry Version: | TRYPSIN INHIB KAZAL |
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| Related: |
Kazal Motifs
MeSH | ||||||
| DeCS ID: | 27874 | ||||||
| Unique ID: | D014359 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2019/04/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Trypsin Inhibitor, Kazal Pancreatic
- Preferred
| Concept UI |
M0022080 |
| Scope note | A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS. |
| Preferred term | Trypsin Inhibitor, Kazal Pancreatic |
| Entry term(s) |
Acidic Pancreatic Trypsin Inhibitor Inhibitor, Tumor-Associated Trypsin Kazal Pancreatic Trypsin Inhibitor Pancreatic Secretory Trypsin Inhibitor Pancreatic Secretory Trypsin Inhibitor, Kazal Pancreatic Trypsin Secretory Inhibitor, Kazal SPINK1 Serine Peptidase Inhibitor, Kazal Type 1 Serine Peptidase Inhibitor, Kazal-Type 1 Serine Protease Inhibitor Kazal Type 1 Serine Protease Inhibitor Kazal-Type 1 Trypsin Inhibitor Kazal Pancreatic Trypsin Inhibitor, Pancreatic Secretory Trypsin Inhibitor, Tumor Associated Trypsin Inhibitor, Tumor-Associated Tumor Associated Trypsin Inhibitor Tumor-Associated Trypsin Inhibitor |
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