PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Molecular Structure [G02.111.570] Molecular Structure Molecular Conformation [G02.111.570.820] Molecular Conformation Protein Conformation [G02.111.570.820.709] Protein Conformation Protein Structural Elements [G02.111.570.820.709.275] Protein Structural Elements Amino Acid Motifs [G02.111.570.820.709.275.500] Amino Acid Motifs Ankyrin Repeat [G02.111.570.820.709.275.500.030] Ankyrin Repeat AT-Hook Motifs [G02.111.570.820.709.275.500.050] AT-Hook Motifs Cystine Knot Motifs [G02.111.570.820.709.275.500.127] Cystine Knot Motifs F-Box Motifs [G02.111.570.820.709.275.500.205] F-Box Motifs Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360] Helix-Loop-Helix Motifs Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440] Immunoreceptor Tyrosine-Based Activation Motif Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480] Immunoreceptor Tyrosine-Based Inhibition Motif Kazal Motifs [G02.111.570.820.709.275.500.490] Kazal Motifs Kelch Repeat [G02.111.570.820.709.275.500.500] Kelch Repeat Leucine Zippers [G02.111.570.820.709.275.500.520] Leucine Zippers Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695] Poly-ADP-Ribose Binding Motif RNA-Binding Motifs [G02.111.570.820.709.275.500.869] RNA-Binding Motifs Sterile Alpha Motif [G02.111.570.820.709.275.500.898] Sterile Alpha Motif AAA Domain [G02.111.570.820.709.275.500.913] AAA Domain Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920] Tetratricopeptide Repeat WD40 Repeats [G02.111.570.820.709.275.500.927] WD40 Repeats Zinc Fingers [G02.111.570.820.709.275.500.985] Zinc Fingers

AAA Domain - Preferred

Concept UI	M000626136
Scope note	An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis.
Preferred term	AAA Domain
Entry term(s)	AAA Domains AAA Module AAA Modules AAA+ Domain AAA+ Domains AAA+ Module AAA+ Modules Domain, AAA Domain, AAA+ Domains, AAA Domains, AAA+ Module, AAA Module, AAA+ Modules, AAA Modules, AAA+

Walker Motifs - Narrower

Concept UI	M000625780
Scope note	Highly conserved amino acid motifs that occur in ATP-binding proteins, especially AAA ATPases. They are characterized by the pattern G-x(4)-GK-[TS]; G, K, T and S are GLYCINE; LYSINE; THREONINE; and SERINE, where x can be any amino acid. This motif binds the beta-phosphate of nucleotides.
Preferred term	Walker Motifs
Entry term(s)	Motif, Walker Motifs, Walker P Loop P-Loop P-Loops Walker Motif

A-Loop - Related but not broader or narrower

Concept UI	M000625783
Preferred term	A-Loop
Entry term(s)	A Loop A-Loops

Walker B Motif - Narrower

Concept UI	M000625782
Preferred term	Walker B Motif
Entry term(s)	B Motif, Walker Motif, Walker B

Walker A Motif - Narrower

Concept UI	M000625781
Preferred term	Walker A Motif
Entry term(s)	A Motif, Walker Motif, Walker A